ID   KDGD2_STRCO             Reviewed;         322 AA.
AC   Q9RDE8;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase 2;
DE            EC=4.2.1.41;
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase 2;
DE            Short=KDGDH 2;
GN   OrderedLocusNames=SCO2543; ORFNames=SCC77.10c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41;
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; AL939113; CAB66221.1; -; Genomic_DNA.
DR   RefSeq; NP_626781.1; NC_003888.3.
DR   RefSeq; WP_011028418.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9RDE8; -.
DR   SMR; Q9RDE8; -.
DR   STRING; 100226.SCO2543; -.
DR   GeneID; 1097977; -.
DR   KEGG; sco:SCO2543; -.
DR   PATRIC; fig|100226.15.peg.2588; -.
DR   eggNOG; COG0329; Bacteria.
DR   HOGENOM; CLU_049343_5_2_11; -.
DR   InParanoid; Q9RDE8; -.
DR   OMA; VLPHYLV; -.
DR   PhylomeDB; Q9RDE8; -.
DR   UniPathway; UPA00564; UER00628.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00951; KDGDH; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..322
FT                   /note="Probable 5-dehydro-4-deoxyglucarate dehydratase 2"
FT                   /id="PRO_0000103242"
SQ   SEQUENCE   322 AA;  33545 MW;  EB54EDC836F5042F CRC64;
     MTSAGPGSDP GTGRAAVVRR LREGMAASVL SFPLTSFHED GSFDADGYRA YVAERLAAGP
     GALFPACGTG EFFSLDEDEY RQAVAIAVEE TAGSVPVVAG TGYGWAQALR FARIAEDAGA
     DALLVMPHYL TAAPQDGLVA QMERIAAGTR LPLIAYQRGQ VAYTAESVRR LTRVPGVIGL
     KDGHSDLDRL QRAVLAAPDD FLFFNGAATA EVQARAYAAV GVPAYSSAVH AFAPEIANAF
     LAALRGGDTG TVDKLLRDFY VPLVELRDRV PGYAVSLVKA AARLRGCPVG PVRAPLTDPS
     PADLAALTTL LTTGLDLVGA AL