KDGD_AGRRK
ID KDGD_AGRRK Reviewed; 302 AA.
AC B9JLF7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN OrderedLocusNames=Arad_9704;
OS Agrobacterium radiobacter (strain K84 / ATCC BAA-868).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC Agrobacterium tumefaciens complex.
OX NCBI_TaxID=311403;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K84 / ATCC BAA-868;
RX PubMed=19251847; DOI=10.1128/jb.01779-08;
RA Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K.,
RA Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L.,
RA Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A.,
RA Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M.,
RA Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N.,
RA Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W.;
RT "Genome sequences of three Agrobacterium biovars help elucidate the
RT evolution of multichromosome genomes in bacteria.";
RL J. Bacteriol. 191:2501-2511(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00694};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
CC -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
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DR EMBL; CP000629; ACM30693.1; -; Genomic_DNA.
DR RefSeq; WP_015917954.1; NC_011983.1.
DR AlphaFoldDB; B9JLF7; -.
DR SMR; B9JLF7; -.
DR STRING; 311403.Arad_9704; -.
DR EnsemblBacteria; ACM30693; ACM30693; Arad_9704.
DR KEGG; ara:Arad_9704; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_2_5; -.
DR OMA; EFHALTP; -.
DR OrthoDB; 1438588at2; -.
DR UniPathway; UPA00564; UER00628.
DR Proteomes; UP000001600; Chromosome 2.
DR GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00951; KDGDH; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00694; KDGDH; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR PANTHER; PTHR12128; PTHR12128; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR TIGRFAMs; TIGR03249; KdgD; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..302
FT /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT /id="PRO_1000147904"
SQ SEQUENCE 302 AA; 32211 MW; E087B4DC81C9B301 CRC64;
MNPLELKKAV GSGLLSFPVT HFDNDLKFDE AKYRRHVEWL SGYDAAALFA AGGTGEFFSL
NPAEVPQVVQ AAKAVAGNTP IISGTGYGTS IAVEIAKSAE KAGADGLLLL PPYLMFAEQE
GLIAHVKAVC QSVGIGVIVY NRDNAILNAD SIARLTDECP NLIGFKDGVG DVDKVIEITT
KLQDRLVYVG GMPTHEVYAQ AYFAAGVTTY SSAVFNFVPA LAQRFYGALR TGDQATVDEI
LKGFFFPFVA LRNRKKGYAV SIIKAGLRVL GQDPGPVRPP LTDLTPEELA ALAQIIETAK
AA
