KDGD_AZOVD
ID KDGD_AZOVD Reviewed; 303 AA.
AC C1DJJ0;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN OrderedLocusNames=Avin_05220;
OS Azotobacter vinelandii (strain DJ / ATCC BAA-1303).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Azotobacter.
OX NCBI_TaxID=322710;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DJ / ATCC BAA-1303;
RX PubMed=19429624; DOI=10.1128/jb.00504-09;
RA Setubal J.C., Dos Santos P., Goldman B.S., Ertesvaag H., Espin G.,
RA Rubio L.M., Valla S., Almeida N.F., Balasubramanian D., Cromes L.,
RA Curatti L., Du Z., Godsy E., Goodner B., Hellner-Burris K., Hernandez J.A.,
RA Houmiel K., Imperial J., Kennedy C., Larson T.J., Latreille P., Ligon L.S.,
RA Lu J., Maerk M., Miller N.M., Norton S., O'Carroll I.P., Paulsen I.,
RA Raulfs E.C., Roemer R., Rosser J., Segura D., Slater S., Stricklin S.L.,
RA Studholme D.J., Sun J., Viana C.J., Wallin E., Wang B., Wheeler C., Zhu H.,
RA Dean D.R., Dixon R., Wood D.;
RT "Genome sequence of Azotobacter vinelandii, an obligate aerobe specialized
RT to support diverse anaerobic metabolic processes.";
RL J. Bacteriol. 191:4534-4545(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00694};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
CC -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
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DR EMBL; CP001157; ACO76775.1; -; Genomic_DNA.
DR RefSeq; WP_012699203.1; NC_012560.1.
DR AlphaFoldDB; C1DJJ0; -.
DR SMR; C1DJJ0; -.
DR STRING; 322710.Avin_05220; -.
DR EnsemblBacteria; ACO76775; ACO76775; Avin_05220.
DR KEGG; avn:Avin_05220; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_2_6; -.
DR OMA; EFHALTP; -.
DR OrthoDB; 1438588at2; -.
DR UniPathway; UPA00564; UER00628.
DR Proteomes; UP000002424; Chromosome.
DR GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00951; KDGDH; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00694; KDGDH; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR PANTHER; PTHR12128; PTHR12128; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR TIGRFAMs; TIGR03249; KdgD; 1.
PE 3: Inferred from homology;
KW Lyase.
FT CHAIN 1..303
FT /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT /id="PRO_1000212623"
SQ SEQUENCE 303 AA; 32652 MW; 7835093016D034DB CRC64;
MTPQELKSIL SSGLLSFPVT DFDAAGDFDA ESYARRLEWL APYGASALFA AGGTGEFFSL
GLDEYPRIIK TAVDTCAGSV PILAGVGGPT RQAIHMAQEA ERLGAKGLLL LPHYLTEASQ
EGVAAHVEAV CRAVKIGVVV YNRNVCRLTP ALLEQLAERC PNLVGYKDGL GEIELMVSVR
HRLGERFAYL GGLPTAEVYA AAYKALGVPV YSSAVFNFIP RTAMEFYKAV AADDQVTVGR
LIDDFFLPLL EIRNRRAGYA VSIVKAGVRV IGHDAGPVRA PLTDLLPDEY ERLAALIRKL
GPQ
