KDGD_BRADU
ID KDGD_BRADU Reviewed; 314 AA.
AC Q89HW8;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN OrderedLocusNames=blr5871;
OS Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS NBRC 14792 / USDA 110).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Bradyrhizobium.
OX NCBI_TaxID=224911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00694};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
CC -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
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DR EMBL; BA000040; BAC51136.1; -; Genomic_DNA.
DR RefSeq; NP_772511.1; NC_004463.1.
DR RefSeq; WP_011088612.1; NZ_CP011360.1.
DR AlphaFoldDB; Q89HW8; -.
DR SMR; Q89HW8; -.
DR STRING; 224911.27354148; -.
DR EnsemblBacteria; BAC51136; BAC51136; BAC51136.
DR GeneID; 64025639; -.
DR KEGG; bja:blr5871; -.
DR PATRIC; fig|224911.44.peg.5817; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_2_5; -.
DR InParanoid; Q89HW8; -.
DR OMA; EFHALTP; -.
DR PhylomeDB; Q89HW8; -.
DR UniPathway; UPA00564; UER00628.
DR Proteomes; UP000002526; Chromosome.
DR GO; GO:0008840; F:4-hydroxy-tetrahydrodipicolinate synthase activity; IBA:GO_Central.
DR GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00951; KDGDH; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00694; KDGDH; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR PANTHER; PTHR12128; PTHR12128; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR TIGRFAMs; TIGR03249; KdgD; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..314
FT /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT /id="PRO_0000103231"
SQ SEQUENCE 314 AA; 33778 MW; 1E7DA313562A6C8C CRC64;
MSKMTPQEMA QTIGSGLLSF PVTPFKADYS FDEATYRANM DWLCGYDVAG LFAAGGTGEF
FSLTPTEVPQ IVKIAVEETK GRVPVLAGTG YGTAIAREIA VGAEKAGADG LLLLPPYLTH
SEQDGLAAHV EAVCAAVKIG VIVYNRDNAI LQPDTLARLA ERCPNLVGYK DGIGDIELMT
RVYTKLGDRL TYIGGLPTAE TFALPYLDMG VTTYSSAVFN FVPEFATNFY AAVRKRDHAT
IHAGLKDFIL PLIAIRNRKK GYAVSIIKAG MKVIGRDSGP VRPPLTDLTE QEIAELTALV
KKLPAIRSSQ QAAE
