KDGD_BRASO
ID KDGD_BRASO Reviewed; 314 AA.
AC A4YNH1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN OrderedLocusNames=BRADO1565;
OS Bradyrhizobium sp. (strain ORS 278).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX NCBI_TaxID=114615;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ORS 278;
RX PubMed=17540897; DOI=10.1126/science.1139548;
RA Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL Science 316:1307-1312(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00694};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
CC -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
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DR EMBL; CU234118; CAL75447.1; -; Genomic_DNA.
DR RefSeq; WP_011924678.1; NC_009445.1.
DR AlphaFoldDB; A4YNH1; -.
DR SMR; A4YNH1; -.
DR STRING; 114615.BRADO1565; -.
DR PRIDE; A4YNH1; -.
DR EnsemblBacteria; CAL75447; CAL75447; BRADO1565.
DR KEGG; bra:BRADO1565; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_2_5; -.
DR OMA; EFHALTP; -.
DR OrthoDB; 1438588at2; -.
DR BioCyc; BSP114615:BRADO_RS07360-MON; -.
DR UniPathway; UPA00564; UER00628.
DR Proteomes; UP000001994; Chromosome.
DR GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00951; KDGDH; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00694; KDGDH; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR PANTHER; PTHR12128; PTHR12128; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR TIGRFAMs; TIGR03249; KdgD; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..314
FT /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT /id="PRO_1000045401"
SQ SEQUENCE 314 AA; 33715 MW; D3AAD82A6BCA4563 CRC64;
MSKMTPQEMA AKIGSGLLSF PVTPFKADYS FDETTYRSNM DWLCGYDVAG LFAAGGTGEF
FSLTAAEVPE VVKVAVDETK GRVPVLAGTG YGTAIAREIA MSAEKAGADG LLLLPPYLMH
AEQEGLAAHV EAVCKSVKIG VIVYNRDNAI LQPDTLARLC ERCPNLVGYK DGIGDIELMT
RVYTKMGDRL TYIGGLPTAE TFALPYLDMG VTTYSSAVFN FVPEFATNFY AAVRKRDHAT
IHAGLKDFIL PLIAIRNRKK GYAVSIIKAG MKVIGRDSGP VRLPLTDLTE AEMAELTALV
KALPVAASAQ QAAE
