ID   KDGD_CORGB              Reviewed;         316 AA.
AC   A4QB97;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE            EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE            Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN   OrderedLocusNames=cgR_0526;
OS   Corynebacterium glutamicum (strain R).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=340322;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R;
RX   PubMed=17379713; DOI=10.1099/mic.0.2006/003657-0;
RA   Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M.,
RA   Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.;
RT   "Comparative analysis of the Corynebacterium glutamicum group and complete
RT   genome sequence of strain R.";
RL   Microbiology 153:1042-1058(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00694};
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC       Rule:MF_00694}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00694}.
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DR   EMBL; AP009044; BAF53494.1; -; Genomic_DNA.
DR   RefSeq; WP_003855604.1; NC_009342.1.
DR   AlphaFoldDB; A4QB97; -.
DR   SMR; A4QB97; -.
DR   EnsemblBacteria; BAF53494; BAF53494; cgR_0526.
DR   GeneID; 58311322; -.
DR   KEGG; cgt:cgR_0526; -.
DR   HOGENOM; CLU_049343_5_2_11; -.
DR   OMA; MVYNRDN; -.
DR   PhylomeDB; A4QB97; -.
DR   UniPathway; UPA00564; UER00628.
DR   Proteomes; UP000006698; Chromosome.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00951; KDGDH; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..316
FT                   /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT                   /id="PRO_1000045402"
SQ   SEQUENCE   316 AA;  33580 MW;  717B373FDCAA5F48 CRC64;
     MARFSPQDLA DHLKDGLLSF PATAFQDDLE VDEVAYVEHI EWQSSYPVAG LFAAGGTGEG
     FSLTVEENHR VTQLAVQASS PEVPVLGSAT GSTKSAIANA QGAEAAGAEG VLLLPPYLTE
     CDAEGLYNHA AAVCESTSLG VIVYNRANAI YSPEVIARLS ERYPNFIGFK DGTGNIEHLA
     KITTLCGDRL FYLGGLPTAE TFALPLLQMG MSTYSSAMFN FIPDFALSFY ADVRAQDSAA
     VKQKLSDFVL PYLDIRDRAQ GYGVSIVKGG LKAVGRNAGG VRPPLRNLSE QDIADLSDLL
     ATSGAGSYRL PVEVKA