KDGD_PSE14
ID KDGD_PSE14 Reviewed; 303 AA.
AC Q48E20;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN OrderedLocusNames=PSPPH_4252;
OS Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)
OS (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=264730;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1448A / Race 6;
RX PubMed=16159782; DOI=10.1128/jb.187.18.6488-6498.2005;
RA Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R.,
RA Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn Giglio M.,
RA Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Crabtree J.,
RA Creasy T., Davidsen T.M., Haft D.H., Zafar N., Zhou L., Halpin R.,
RA Holley T., Khouri H.M., Feldblyum T.V., White O., Fraser C.M.,
RA Chatterjee A.K., Cartinhour S., Schneider D., Mansfield J.W., Collmer A.,
RA Buell R.;
RT "Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola
RT 1448A reveals divergence among pathovars in genes involved in virulence and
RT transposition.";
RL J. Bacteriol. 187:6488-6498(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00694};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
CC -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
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DR EMBL; CP000058; AAZ34628.1; -; Genomic_DNA.
DR RefSeq; WP_004656752.1; NC_005773.3.
DR AlphaFoldDB; Q48E20; -.
DR SMR; Q48E20; -.
DR STRING; 264730.PSPPH_4252; -.
DR EnsemblBacteria; AAZ34628; AAZ34628; PSPPH_4252.
DR KEGG; psp:PSPPH_4252; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_2_6; -.
DR OMA; EFHALTP; -.
DR OrthoDB; 1438588at2; -.
DR UniPathway; UPA00564; UER00628.
DR Proteomes; UP000000551; Chromosome.
DR GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00951; KDGDH; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00694; KDGDH; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR PANTHER; PTHR12128; PTHR12128; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR TIGRFAMs; TIGR03249; KdgD; 1.
PE 3: Inferred from homology;
KW Lyase.
FT CHAIN 1..303
FT /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT /id="PRO_1000045406"
SQ SEQUENCE 303 AA; 32723 MW; 3A26B0F50B1252C7 CRC64;
MNPQELKSIL SSGLLSFPVT DFNAQGDFHR AGYIKRLEWL APYGASALFA AGGTGEFFSL
AASEYSEIIK TAVDTCATSV PILAGVGGPT RQAIEYAQEA ERLGAKGLLL LPHYLTEASQ
DGVAAHVEAV CKAVKIGVVV YNRNVCRLTP TLLEQLAERC PNLIGYKDGL GDIELMVSIR
RRLGDRFSYL GGLPTAEVYA AAYKALGVPV YSSAVFNFVP KLAMDFYHAI ARDDHEAVGK
YIDDFFLPYL EIRNRKAGYA VSIVKAGAKI AGYDAGPVRA PLTDLTPDEC DMLAALMDKQ
GKQ
