ID   KDGD_PSEPU              Reviewed;         303 AA.
AC   P42233;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=5-dehydro-4-deoxyglucarate dehydratase;
DE            EC=4.2.1.41;
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase;
DE            Short=KDGDH;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=pp3;
RA   Burlingame R.P., Lauer G.D., Platz J.G., Rudd E.A., Ally A., Ally D.,
RA   Backman K.C.;
RT   "Nucleotide sequence of genes for glucarate dehydratase and 5-keto-4-
RT   deoxyglucarate dehydratase from Pseudomonas putida pp3.";
RL   Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41;
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000305}.
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DR   EMBL; M69160; AAA25869.1; -; Genomic_DNA.
DR   PIR; S27618; S27618.
DR   AlphaFoldDB; P42233; -.
DR   SMR; P42233; -.
DR   UniPathway; UPA00564; UER00628.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00951; KDGDH; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   TIGRFAMs; TIGR03249; KdgD; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..303
FT                   /note="5-dehydro-4-deoxyglucarate dehydratase"
FT                   /id="PRO_0000103235"
SQ   SEQUENCE   303 AA;  32808 MW;  9B933EC14CF4D5E5 CRC64;
     MNPQELKSIL SEGLLSFPLT DFDVAGDFRA DTYAKRLEWL APYGASALFA AGGTGEFFSL
     QASEYSEIIK VAVDTCRGEV PILAGTGGPT RQAIAYAQEA ERLGAAGVLL LPHYLTEASQ
     EGLVSHVEQV CKSVDFGVVV YNRNVCRLNA DSLEKLADRC PNLIGFKDGV GDIESMVSIR
     RRLGERLTYL GGLPTAEVYA AAYKAMGVPV YSSAVFNFIP KTAMDFYRAV ASEDHETVGK
     LIDDFFLPYL DIRNRCEGYG VSIVKAGARL VGHDAGPVRA PLTDLLPNEM EQLDALIKKL
     GAQ