ID   KDGD_STRGG              Reviewed;         320 AA.
AC   B1W1P9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Probable 5-dehydro-4-deoxyglucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE            EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE   AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE            Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN   OrderedLocusNames=SGR_5617;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC         CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC         ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00694};
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC       dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC       Rule:MF_00694}.
CC   -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00694}.
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DR   EMBL; AP009493; BAG22446.1; -; Genomic_DNA.
DR   RefSeq; WP_012381423.1; NC_010572.1.
DR   AlphaFoldDB; B1W1P9; -.
DR   SMR; B1W1P9; -.
DR   STRING; 455632.SGR_5617; -.
DR   EnsemblBacteria; BAG22446; BAG22446; SGR_5617.
DR   GeneID; 6209031; -.
DR   KEGG; sgr:SGR_5617; -.
DR   PATRIC; fig|455632.4.peg.5754; -.
DR   eggNOG; COG0329; Bacteria.
DR   HOGENOM; CLU_049343_5_2_11; -.
DR   OMA; EFHALTP; -.
DR   OrthoDB; 1438588at2; -.
DR   UniPathway; UPA00564; UER00628.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00694; KDGDH; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR   PANTHER; PTHR12128; PTHR12128; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   SMART; SM01130; DHDPS; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..320
FT                   /note="Probable 5-dehydro-4-deoxyglucarate dehydratase"
FT                   /id="PRO_1000132274"
SQ   SEQUENCE   320 AA;  33058 MW;  62846ED4A809C40C CRC64;
     MTSAPLAARL RDVAGPLFFP VTAFGPDGAV DLAVFRAHVR AGIDAGAAAV FACCGTGEFH
     ALTPEEFRLA VGAAVEESAG QVPVLAGAGY GTALAVQYAR AAEEAGADGL LAMPPYLVVA
     DQQGLLHHYA ALAAATGLET IVYQRDNAVF TPETVVALAR TPGVIGLKDG HGDLDLMQRI
     VSAVRTHRPG GDFLYFNGLP TAELTGPAYR GIGVTLYSSA VFAFAPDIAL AFYRALDSGD
     DALVDGLLDH FYRPLVELRA QGRGYAVSLV KAGVRLQGLD VGEVRTPLTE PTAAHVKDLI
     EIIASGRALL AEHAAAGGGA