ID   KDGR_BACSU              Reviewed;         339 AA.
AC   P50844;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=HTH-type transcriptional regulator KdgR;
DE   AltName: Full=Kdg operon repressor;
GN   Name=kdgR; OrderedLocusNames=BSU22120;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8760912; DOI=10.1099/13500872-142-8-2005;
RA   Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D.,
RA   Serror P.;
RT   "Sequence analysis of the Bacillus subtilis chromosome region between the
RT   serA and kdg loci cloned in a yeast artificial chromosome.";
RL   Microbiology 142:2005-2016(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION IN REGULATION OF KDGRKAT EXPRESSION, AND INDUCTION.
RC   STRAIN=168;
RX   PubMed=9846747; DOI=10.1099/00221287-144-11-3111;
RA   Pujic P., Dervyn R., Sorokin A., Ehrlich S.D.;
RT   "The kdgRKAT operon of Bacillus subtilis: detection of the transcript and
RT   regulation by the kdgR and ccpA genes.";
RL   Microbiology 144:3111-3118(1998).
RN   [4]
RP   FUNCTION IN REGULATION OF KDUID EXPRESSION, AND DNA-BINDING.
RC   STRAIN=168;
RX   PubMed=17322190; DOI=10.1099/mic.0.2006/002253-0;
RA   Lin J.S., Shaw G.C.;
RT   "Regulation of the kduID operon of Bacillus subtilis by the KdgR repressor
RT   and the ccpA gene: identification of two KdgR-binding sites within the
RT   kdgR-kduI intergenic region.";
RL   Microbiology 153:701-710(2007).
CC   -!- FUNCTION: Transcriptional repressor of the kdgRKAT and kduID operons
CC       for pectin utilization. {ECO:0000269|PubMed:17322190,
CC       ECO:0000269|PubMed:9846747}.
CC   -!- INDUCTION: Induced by galacturonate and negatively regulated by itself.
CC       Is subject to catabolite repression by glucose involving the ccpA gene.
CC       {ECO:0000269|PubMed:9846747}.
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DR   EMBL; L47838; AAB38478.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14129.1; -; Genomic_DNA.
DR   PIR; B69648; B69648.
DR   RefSeq; NP_390094.1; NC_000964.3.
DR   RefSeq; WP_003230725.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P50844; -.
DR   SMR; P50844; -.
DR   STRING; 224308.BSU22120; -.
DR   PaxDb; P50844; -.
DR   PRIDE; P50844; -.
DR   EnsemblBacteria; CAB14129; CAB14129; BSU_22120.
DR   GeneID; 939063; -.
DR   KEGG; bsu:BSU22120; -.
DR   PATRIC; fig|224308.179.peg.2416; -.
DR   eggNOG; COG1609; Bacteria.
DR   InParanoid; P50844; -.
DR   OMA; MHGVETA; -.
DR   PhylomeDB; P50844; -.
DR   BioCyc; BSUB:BSU22120-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..339
FT                   /note="HTH-type transcriptional regulator KdgR"
FT                   /id="PRO_0000107961"
FT   DOMAIN          9..64
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        11..30
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   339 AA;  37858 MW;  E5D292FEBA1C445B CRC64;
     MKKKTTGHTT IKDVAECAGV SKSTVSRYIN GKIDAISPEK VKNIKKAIAE LNYRPSKMAQ
     GLKIKKSKLI GFVVADITNP FSVAAFRGVE EVCDQYGYSI MVCNTDNSPE KEREMLLKLE
     AHSVEGLILN ATGENKDVLR AFAEQQIPTI LIDRKLPDLK LDTVTTDNRW ITKEILQKVY
     SKGYTDVALF TEPISSISPR AERAAVYQEM ASVQNVNGLV RLHEIDVKDK EQLKAELRSF
     HKEMPEQKKA ILALNGLIML KIISCMEELG LRIPQDIGIA GFDDTEWYKL IGPGITTIAQ
     PSHDMGRTAM ERVLKRIEGD KGAPQTIELE AKVIMRKSL