KDGR_ECOLI
ID KDGR_ECOLI Reviewed; 263 AA.
AC P76268; O07975;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Transcriptional regulator KdgR;
GN Name=kdgR; Synonyms=yebP; OrderedLocusNames=b1827, JW1816;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 88-263.
RG Midwest center for structural genomics (MCSG);
RT "Structural study of effector binding specificity in iclR transcriptional
RT regulators.";
RL Submitted (MAR-2005) to the PDB data bank.
CC -!- FUNCTION: Transcriptional regulator of the kdgK gene for the kdg kinase
CC and the kdgT gene for the kdg permease.
CC -!- INTERACTION:
CC P76268; P64503: yebV; NbExp=3; IntAct=EBI-1123676, EBI-9126792;
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DR EMBL; U00096; AAC74897.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15635.1; -; Genomic_DNA.
DR PIR; C64944; C64944.
DR RefSeq; NP_416341.1; NC_000913.3.
DR RefSeq; WP_001262203.1; NZ_LN832404.1.
DR PDB; 1YSP; X-ray; 1.80 A; A=88-263.
DR PDBsum; 1YSP; -.
DR AlphaFoldDB; P76268; -.
DR SMR; P76268; -.
DR BioGRID; 4261734; 17.
DR BioGRID; 850489; 1.
DR DIP; DIP-10057N; -.
DR IntAct; P76268; 4.
DR STRING; 511145.b1827; -.
DR jPOST; P76268; -.
DR PaxDb; P76268; -.
DR PRIDE; P76268; -.
DR EnsemblBacteria; AAC74897; AAC74897; b1827.
DR EnsemblBacteria; BAA15635; BAA15635; BAA15635.
DR GeneID; 946129; -.
DR KEGG; ecj:JW1816; -.
DR KEGG; eco:b1827; -.
DR PATRIC; fig|1411691.4.peg.423; -.
DR EchoBASE; EB3772; -.
DR eggNOG; COG1414; Bacteria.
DR HOGENOM; CLU_062618_6_0_6; -.
DR InParanoid; P76268; -.
DR OMA; RHSMRMF; -.
DR PhylomeDB; P76268; -.
DR BioCyc; EcoCyc:G7003-MON; -.
DR EvolutionaryTrace; P76268; -.
DR PRO; PR:P76268; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..263
FT /note="Transcriptional regulator KdgR"
FT /id="PRO_0000201760"
FT DOMAIN 13..74
FT /note="HTH iclR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT DOMAIN 89..258
FT /note="IclR-ED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT DNA_BIND 34..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT HELIX 88..104
FT /evidence="ECO:0007829|PDB:1YSP"
FT STRAND 108..114
FT /evidence="ECO:0007829|PDB:1YSP"
FT STRAND 117..124
FT /evidence="ECO:0007829|PDB:1YSP"
FT STRAND 139..145
FT /evidence="ECO:0007829|PDB:1YSP"
FT HELIX 146..153
FT /evidence="ECO:0007829|PDB:1YSP"
FT HELIX 157..164
FT /evidence="ECO:0007829|PDB:1YSP"
FT HELIX 180..193
FT /evidence="ECO:0007829|PDB:1YSP"
FT STRAND 196..203
FT /evidence="ECO:0007829|PDB:1YSP"
FT STRAND 206..214
FT /evidence="ECO:0007829|PDB:1YSP"
FT STRAND 220..226
FT /evidence="ECO:0007829|PDB:1YSP"
FT STRAND 229..232
FT /evidence="ECO:0007829|PDB:1YSP"
FT HELIX 235..255
FT /evidence="ECO:0007829|PDB:1YSP"
SQ SEQUENCE 263 AA; 30029 MW; 5744F66467922C72 CRC64;
MANADLDKQP DSVSSVLKVF GILQALGEER EIGITELSQR VMMSKSTVYR FLQTMKTLGY
VAQEGESEKY SLTLKLFELG ARALQNVDLI RSADIQMREL SRLTKETIHL GALDEDSIVY
IHKIDSMYNL RMYSRIGRRN PLYSTAIGKV LLAWRDRDEV KQILEGVEYK RSTERTITST
EALLPVLDQV REQGYGEDNE EQEEGLRCIA VPVFDRFGVV IAGLSISFPT LRFSEERLQE
YVAMLHTAAR KISAQMGYHD YPF
