KDGT_BACSU
ID KDGT_BACSU Reviewed; 330 AA.
AC P50847;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=2-keto-3-deoxygluconate permease;
DE Short=KDG permease;
GN Name=kdgT; OrderedLocusNames=BSU22090;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=8760912; DOI=10.1099/13500872-142-8-2005;
RA Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D.,
RA Serror P.;
RT "Sequence analysis of the Bacillus subtilis chromosome region between the
RT serA and kdg loci cloned in a yeast artificial chromosome.";
RL Microbiology 142:2005-2016(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP INDUCTION.
RC STRAIN=168;
RX PubMed=9846747; DOI=10.1099/00221287-144-11-3111;
RA Pujic P., Dervyn R., Sorokin A., Ehrlich S.D.;
RT "The kdgRKAT operon of Bacillus subtilis: detection of the transcript and
RT regulation by the kdgR and ccpA genes.";
RL Microbiology 144:3111-3118(1998).
CC -!- FUNCTION: The 2-keto-3-deoxygluconate permease transports the degraded
CC pectin products into the bacterial cell, where they serve as carbon and
CC energy sources. This is a hydrogen coupled transport system (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- INDUCTION: Induced by galacturonate and negatively regulated by the
CC KdgR repressor. Is subject to catabolite repression by glucose
CC involving the ccpA gene. {ECO:0000269|PubMed:9846747}.
CC -!- SIMILARITY: Belongs to the KdgT transporter family. {ECO:0000305}.
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DR EMBL; L47838; AAB38481.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14126.1; -; Genomic_DNA.
DR PIR; C69648; C69648.
DR RefSeq; NP_390091.1; NC_000964.3.
DR RefSeq; WP_003230734.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P50847; -.
DR STRING; 224308.BSU22090; -.
DR TCDB; 2.A.10.1.3; the 2-keto-3-deoxygluconate transporter (kdgt) family.
DR PaxDb; P50847; -.
DR EnsemblBacteria; CAB14126; CAB14126; BSU_22090.
DR GeneID; 939065; -.
DR KEGG; bsu:BSU22090; -.
DR PATRIC; fig|224308.179.peg.2413; -.
DR eggNOG; ENOG502Z7JT; Bacteria.
DR InParanoid; P50847; -.
DR OMA; ESGPFMT; -.
DR PhylomeDB; P50847; -.
DR BioCyc; BSUB:BSU22090-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015649; F:2-keto-3-deoxygluconate:proton symporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00070; KdgT; 1.
DR InterPro; IPR004684; 2keto-3dGluconate_permease.
DR InterPro; IPR018395; 2keto-3dGluconate_permease_sub.
DR Pfam; PF03812; KdgT; 1.
DR TIGRFAMs; TIGR00793; kdgT; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..330
FT /note="2-keto-3-deoxygluconate permease"
FT /id="PRO_0000209674"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 330 AA; 34319 MW; 6273AF3326BD99B6 CRC64;
MKIKATIERV PGGMMIIPLF LGAALNTFAP GTAEFFGGFT GALITGTLPI LGVFIFCVGA
TIDFRSSGYI ARKGITLLLG KIGFAALLGV IAAQFIPDDG IQSGFFAGLS VLAIVAVMNE
TNGGLYLALM NHMGRKEDAG AFAFISTESG PFMTMVTFGV TGLAAFPWET LAATVIPFLL
GCILGNLDHD LRDLFSKVVP AIIPFFAFSL GNTLNFGMLI QSGLLGIFIG VSVVILSGSS
LFLLDRFIAR GDGVAGVAAS STAGAAVAVP YALAEANASF APVAESATAI IATSVIVTSL
LTPLATVWVD KKIKQKKRRT PPPKNQMTIN
