KDGT_ECOLI
ID KDGT_ECOLI Reviewed; 327 AA.
AC P0A712; P32172; Q2M8K6;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=2-keto-3-deoxygluconate permease;
DE Short=KDG permease;
GN Name=kdgT; OrderedLocusNames=b3909, JW5560;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8346018; DOI=10.1093/nar/21.15.3391;
RA Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome. III. DNA sequence of the region
RT from 87.2 to 89.2 minutes.";
RL Nucleic Acids Res. 21:3391-3398(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: The 2-keto-3-deoxygluconate permease transports the degraded
CC pectin products into the bacterial cell, where they serve as carbon and
CC energy sources. This is a hydrogen coupled transport system.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the KdgT transporter family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB03042.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; L19201; AAB03042.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76891.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE77400.1; -; Genomic_DNA.
DR PIR; S40853; S40853.
DR RefSeq; NP_418345.2; NC_000913.3.
DR RefSeq; WP_001166063.1; NZ_SSZK01000014.1.
DR AlphaFoldDB; P0A712; -.
DR BioGRID; 4259555; 9.
DR STRING; 511145.b3909; -.
DR TCDB; 2.A.10.1.2; the 2-keto-3-deoxygluconate transporter (kdgt) family.
DR PaxDb; P0A712; -.
DR PRIDE; P0A712; -.
DR EnsemblBacteria; AAC76891; AAC76891; b3909.
DR EnsemblBacteria; BAE77400; BAE77400; BAE77400.
DR GeneID; 66672182; -.
DR GeneID; 948407; -.
DR KEGG; ecj:JW5560; -.
DR KEGG; eco:b3909; -.
DR PATRIC; fig|1411691.4.peg.2795; -.
DR EchoBASE; EB1815; -.
DR eggNOG; ENOG502Z7JT; Bacteria.
DR HOGENOM; CLU_057476_0_1_6; -.
DR InParanoid; P0A712; -.
DR OMA; ESGPFMT; -.
DR PhylomeDB; P0A712; -.
DR BioCyc; EcoCyc:KDGT-MON; -.
DR BioCyc; MetaCyc:KDGT-MON; -.
DR PRO; PR:P0A712; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IDA:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015649; F:2-keto-3-deoxygluconate:proton symporter activity; IDA:EcoCyc.
DR GO; GO:0035429; P:gluconate transmembrane transport; IDA:EcoCyc.
DR HAMAP; MF_00070; KdgT; 1.
DR InterPro; IPR004684; 2keto-3dGluconate_permease.
DR InterPro; IPR018395; 2keto-3dGluconate_permease_sub.
DR Pfam; PF03812; KdgT; 1.
DR TIGRFAMs; TIGR00793; kdgT; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..327
FT /note="2-keto-3-deoxygluconate permease"
FT /id="PRO_0000209675"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..41
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..162
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..223
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..288
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 327 AA; 33669 MW; 8F870CB233B35453 CRC64;
MQIKRSIEKI PGGMMLVPLF LGALCHTFSP GAGKYFGSFT NGMITGTVPI LAVWFFCMGA
SIKLSATGTV LRKSGTLVVT KIAVAWVVAA IASRIIPEHG VEVGFFAGLS TLALVAAMDM
TNGGLYASIM QQYGTKEEAG AFVLMSLESG PLMTMIILGT AGIASFEPHV FVGAVLPFLV
GFALGNLDPE LREFFSKAVQ TLIPFFAFAL GNTIDLTVIA QTGLLGILLG VAVIIVTGIP
LIIADKLIGG GDGTAGIAAS SSAGAAVATP VLIAEMVPAF KPMAPAATSL VATAVIVTSI
LVPILTSIWS RKVKARAAKI EILGTVK
