KDISB_DANRE
ID KDISB_DANRE Reviewed; 1680 AA.
AC Q7T163; Q5TZ97; Q6P7Y1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2017, sequence version 3.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Kinase D-interacting substrate of 220 kDa B {ECO:0000305};
DE AltName: Full=Ankyrin repeat-rich membrane-spanning protein B {ECO:0000305};
GN Name=kidins220b {ECO:0000312|ZFIN:ZDB-GENE-030131-7824};
GN Synonyms=arms {ECO:0000312|ZFIN:ZDB-GENE-030131-7824},
GN kidins220 {ECO:0000303|PubMed:22609016};
GN ORFNames=si:dkeyp-7f8.3, si:dz119j18.2, zgc:63531;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH PDZRN3B, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND
RP MOTIF.
RX PubMed=22609016; DOI=10.1016/j.biochi.2012.05.002;
RA Andreazzoli M., Gestri G., Landi E., D'Orsi B., Barilari M., Iervolino A.,
RA Vitiello M., Wilson S.W., Dente L.;
RT "Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple
RT binding domains.";
RL Biochimie 94:2054-2057(2012).
CC -!- FUNCTION: Downstream target for both neurotrophin and ephrin receptors.
CC May play a role in nerve growth factor (NGF)-induced recruitment of
CC rapgef2 to late endosomes and neurite outgrowth.
CC {ECO:0000250|UniProtKB:Q9EQG6}.
CC -!- SUBUNIT: Interacts (via PDZ-binding motif) with pdzrn3b (via PDZ domain
CC 1). {ECO:0000269|PubMed:22609016}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}. Late endosome membrane
CC {ECO:0000250|UniProtKB:Q9EQG6}; Multi-pass membrane protein
CC {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:22609016}.
CC -!- DEVELOPMENTAL STAGE: Detected in notochord and brain at the 14-somite
CC stage. Expressed in the ventral region of the eye and in spinal motor
CC neurons at 32 hours post-fertilization. {ECO:0000269|PubMed:22609016}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH61450.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL954721; CAE17588.1; -; Genomic_DNA.
DR EMBL; BX293564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC061450; AAH61450.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q7T163; -.
DR SMR; Q7T163; -.
DR STRING; 7955.ENSDARP00000092376; -.
DR PaxDb; Q7T163; -.
DR ZFIN; ZDB-GENE-030131-7824; kidins220b.
DR eggNOG; KOG0502; Eukaryota.
DR InParanoid; Q7T163; -.
DR PhylomeDB; Q7T163; -.
DR Reactome; R-DRE-170984; ARMS-mediated activation.
DR Reactome; R-DRE-9696270; RND2 GTPase cycle.
DR Reactome; R-DRE-9696273; RND1 GTPase cycle.
DR PRO; PR:Q7T163; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030165; F:PDZ domain binding; IPI:ZFIN.
DR GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 10.
PE 1: Evidence at protein level;
KW ANK repeat; Cytoplasm; Endosome; Membrane; Neurogenesis;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..1680
FT /note="Kinase D-interacting substrate of 220 kDa B"
FT /id="PRO_0000322121"
FT TOPO_DOM 1..508
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 530..533
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 555..668
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 690..696
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 697..717
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 718..1680
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 45..74
FT /note="ANK 1"
FT REPEAT 78..107
FT /note="ANK 2"
FT REPEAT 111..140
FT /note="ANK 3"
FT REPEAT 145..174
FT /note="ANK 4"
FT REPEAT 178..207
FT /note="ANK 5"
FT REPEAT 211..240
FT /note="ANK 6"
FT REPEAT 244..273
FT /note="ANK 7"
FT REPEAT 277..306
FT /note="ANK 8"
FT REPEAT 310..339
FT /note="ANK 9"
FT REPEAT 343..372
FT /note="ANK 10"
FT REPEAT 376..405
FT /note="ANK 11"
FT DOMAIN 449..960
FT /note="KAP NTPase"
FT REGION 1362..1554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1574..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1675..1680
FT /note="PDZ-binding"
FT /evidence="ECO:0000269|PubMed:22609016"
FT COMPBIAS 1364..1386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1407..1421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1514..1543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 474..475
FT /note="YA -> NT (in Ref. 2; AAH61450)"
FT /evidence="ECO:0000305"
FT CONFLICT 552
FT /note="V -> L (in Ref. 2; AAH61450)"
FT /evidence="ECO:0000305"
FT CONFLICT 1302
FT /note="T -> A (in Ref. 2; AAH61450)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1680 AA; 185949 MW; 4FE8AB3377DD5E60 CRC64;
MDTTTSIKMT TLAIQNLFSY VEEENLAAVK VHLDKFKEVD GRSDNGQTPL MLASEQGSLE
IVQELIRRGA NVNLDDVDCW SALISAAKEG HVEVVKELLE NSAYIEHRDM GGWTALTWAS
YKGRVEVATV LLENGANPNT TGQQYSVYPI IWAAGRGHAE IVKLLLEHGA KVNCSDKYGT
TPLIWAARKG HYDCVMHLLE NGADVDQEGA NSMTALIVAV KGGYTEVVKE LLKRNPNVNM
TDKDGNTALM IAAKEGYTEI VQDLLDAGTY VNIPDRSGDT VLIGAVRGGH VEIVRALLHK
YADIDIRGQE NKTALYWAVE KGNATMVRDI LQCNPDTETT TKDSETPLIK ATKMRSIEVV
ELLLDKGAKV SAVDKRGDTP LHIAIRGRSR RLAELLLRNP KDGRLLYRPN KAGETPYNID
CSHQKSILTQ IFGARHLSPT ESDGDMLGYD LYSSALADIL SEPTMQPPIC VGLYAQWGSG
KSFLLKKLED EMKTFAGQQV EPLFQFSWLV VLLSLLLCGS VALVLGFTVD PKLAIAISLS
ILALLYVFFV VVYFGSRREG ESWNWAWVIS TRLARHIGYL ELLLKLMFVN PPELPEQTTR
ALPVRFLFTD YNRLSSVGGE TSMAEMIATL SDACEREFGF LATRLFRVFK TEDTQGKKKW
KKTCCIPSFV IFLFILGCLI MGMALLAVFK VDGQNQTVNA VLVSMASVVG LALLLNCRTW
WQVTDSVLNS QRKRLHSAAN KMHKLKSEGF MKVLKNEVEL MAKMAKTIDG FTQNQTRLVV
IIDGLDSCEQ DKVLQMLDTV RVLFSKGPFI SIFASDPHII IKAINQNLNS VLRDSNINGH
DYMRNIVHLP VFLNSRGLSS AKKMCAPAPA NGETGNSEGW HEELDRKLSQ NSLGDQTKFG
SKTTLNRRDT YRRRQMQRSV TRQMSFDLTK LLVTEDWFSD ISPQTMRRLL NIVSVTGRLL
RANQISFNWD RLASWINLTE QWPYRTSWLI LYLEETDGIP DQTNLKTIYE RISKNIPTTK
DVEPLLEIDG DVRSFEVFLS SRTPVLAARD IRTFLPCTVN LDPKLREIIA DVRAAREQVN
MAGVTYPTLP LQEGRPISMY SQQSSACSPT ASFNGPYNPP GVSPQPHSAY FSGMAGPQHP
FYNRGSASVV SGTPSILLSS MSTDVICERV KLIDGIDQNL ISQYTATIKK ANINGRVLSQ
CNIDELKKEM NMNFGDWQLF RTSVLEMRHV ENQVLHEEAP SEQGSITVGH VEPCRHAGAA
AQGVAGNTDT SPMYNFNLSF EELSNVGLEE PPRHVNATWM GTTHRTPSMS SLNSQESSNE
ICKLTDKQQA EYRNAYEDYI ASMSQLELGM EKPVPPFVSQ LMHSSSEDKK KDGNDQDGRK
SVSKRGSTKS GSDNTDYASA DAATLDPITE EDEKVDHGSS KSLLGRKTSG DKVSLFQGAD
LKLKAGGGSR YQKLTSDDEE SEESDNAPLL KDGKKPEAKA SDGGDRSLTK GKDYLSDKKD
SSDSGVRSNE SSPNHSLQDE EADLSQSERA NLIELDEENS ARKRGLPNSL SGLQDPTIAR
MSICSEDQCS LLASSPEESW PSSKSYNLNR TPSNTTLNNN TNAQQGNHIR QPSDSSNTTS
TTTGSDVIIN PGTSTTSATT QNENVRVVHL KRGLNPGDPP EILKVSSETV TFGEERESIL
