AQP6_HUMAN
ID AQP6_HUMAN Reviewed; 282 AA.
AC Q13520;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Aquaporin-6;
DE Short=AQP-6;
DE AltName: Full=Aquaporin-2-like;
DE AltName: Full=Kidney-specific aquaporin;
DE Short=hKID;
GN Name=AQP6; Synonyms=AQP2L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=8812490; DOI=10.1006/geno.1996.0396;
RA Ma T., Yang B., Kuo W.L., Verkman A.S.;
RT "cDNA cloning and gene structure of a novel water channel expressed
RT exclusively in human kidney: evidence for a gene cluster of aquaporins at
RT chromosome locus 12q13.";
RL Genomics 35:543-550(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- FUNCTION: Forms a water-specific channel that participates in distinct
CC physiological functions such as glomerular filtration, tubular
CC endocytosis and acid-base metabolism. {ECO:0000250}.
CC -!- INTERACTION:
CC Q13520; P45844-4: ABCG1; NbExp=3; IntAct=EBI-13059134, EBI-8584087;
CC Q13520; O95870: ABHD16A; NbExp=3; IntAct=EBI-13059134, EBI-348517;
CC Q13520; Q9ULC5: ACSL5; NbExp=3; IntAct=EBI-13059134, EBI-2876927;
CC Q13520; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-13059134, EBI-11277970;
CC Q13520; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-13059134, EBI-10827839;
CC Q13520; Q6ZNB7: AGMO; NbExp=3; IntAct=EBI-13059134, EBI-18509181;
CC Q13520; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-13059134, EBI-2803601;
CC Q13520; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-13059134, EBI-1754287;
CC Q13520; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-13059134, EBI-11522760;
CC Q13520; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-13059134, EBI-11957045;
CC Q13520; P20292: ALOX5AP; NbExp=3; IntAct=EBI-13059134, EBI-3904621;
CC Q13520; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-13059134, EBI-12109402;
CC Q13520; O75106: AOC2; NbExp=3; IntAct=EBI-13059134, EBI-17685278;
CC Q13520; P02652: APOA2; NbExp=3; IntAct=EBI-13059134, EBI-1171525;
CC Q13520; P29972: AQP1; NbExp=3; IntAct=EBI-13059134, EBI-745213;
CC Q13520; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-13059134, EBI-714543;
CC Q13520; Q8N6S5: ARL6IP6; NbExp=3; IntAct=EBI-13059134, EBI-2808844;
CC Q13520; Q9H2C2: ARV1; NbExp=3; IntAct=EBI-13059134, EBI-11724186;
CC Q13520; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-13059134, EBI-12069500;
CC Q13520; P27449: ATP6V0C; NbExp=3; IntAct=EBI-13059134, EBI-721179;
CC Q13520; O15155: BET1; NbExp=3; IntAct=EBI-13059134, EBI-749204;
CC Q13520; O95393: BMP10; NbExp=3; IntAct=EBI-13059134, EBI-3922513;
CC Q13520; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-13059134, EBI-12244618;
CC Q13520; P35613-2: BSG; NbExp=3; IntAct=EBI-13059134, EBI-11037868;
CC Q13520; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-13059134, EBI-8648738;
CC Q13520; O14523: C2CD2L; NbExp=3; IntAct=EBI-13059134, EBI-12822627;
CC Q13520; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-13059134, EBI-12003442;
CC Q13520; P01031: C5; NbExp=3; IntAct=EBI-13059134, EBI-8558308;
CC Q13520; Q6UWT4: C5orf46; NbExp=3; IntAct=EBI-13059134, EBI-11986083;
CC Q13520; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-13059134, EBI-9083477;
CC Q13520; O00626: CCL22; NbExp=3; IntAct=EBI-13059134, EBI-3907871;
CC Q13520; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-13059134, EBI-10271156;
CC Q13520; P34810: CD68; NbExp=3; IntAct=EBI-13059134, EBI-2826276;
CC Q13520; P60033: CD81; NbExp=3; IntAct=EBI-13059134, EBI-712921;
CC Q13520; O14735: CDIPT; NbExp=3; IntAct=EBI-13059134, EBI-358858;
CC Q13520; Q6IBD0: CDW52; NbExp=3; IntAct=EBI-13059134, EBI-12011352;
CC Q13520; A0A4W8VYG7: CGREF1; NbExp=3; IntAct=EBI-13059134, EBI-23781855;
CC Q13520; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-13059134, EBI-12256978;
CC Q13520; O14493: CLDN4; NbExp=3; IntAct=EBI-13059134, EBI-9316372;
CC Q13520; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-13059134, EBI-11959453;
CC Q13520; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-13059134, EBI-7247651;
CC Q13520; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-13059134, EBI-11522780;
CC Q13520; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-13059134, EBI-2807956;
CC Q13520; O95406: CNIH1; NbExp=3; IntAct=EBI-13059134, EBI-12172273;
CC Q13520; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-13059134, EBI-12208021;
CC Q13520; Q9Y5Q5: CORIN; NbExp=3; IntAct=EBI-13059134, EBI-17876114;
CC Q13520; Q5RI15: COX20; NbExp=3; IntAct=EBI-13059134, EBI-2834035;
CC Q13520; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-13059134, EBI-12019274;
CC Q13520; Q07325: CXCL9; NbExp=3; IntAct=EBI-13059134, EBI-3911467;
CC Q13520; Q5JRM2: CXorf66; NbExp=3; IntAct=EBI-13059134, EBI-12823659;
CC Q13520; P49447: CYB561; NbExp=3; IntAct=EBI-13059134, EBI-8646596;
CC Q13520; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-13059134, EBI-10269179;
CC Q13520; Q8N8Q1: CYB561D1; NbExp=3; IntAct=EBI-13059134, EBI-12873482;
CC Q13520; O43169: CYB5B; NbExp=3; IntAct=EBI-13059134, EBI-1058710;
CC Q13520; P00387: CYB5R3; NbExp=3; IntAct=EBI-13059134, EBI-1046040;
CC Q13520; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-13059134, EBI-2680384;
CC Q13520; P78329: CYP4F2; NbExp=3; IntAct=EBI-13059134, EBI-1752413;
CC Q13520; Q6NT55: CYP4F22; NbExp=3; IntAct=EBI-13059134, EBI-17509525;
CC Q13520; P81534: DEFB103B; NbExp=3; IntAct=EBI-13059134, EBI-12074168;
CC Q13520; Q8NET1: DEFB108B; NbExp=3; IntAct=EBI-13059134, EBI-13346443;
CC Q13520; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-13059134, EBI-10305240;
CC Q13520; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-13059134, EBI-398977;
CC Q13520; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-13059134, EBI-12831978;
CC Q13520; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-13059134, EBI-3923585;
CC Q13520; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-13059134, EBI-8639143;
CC Q13520; Q15125: EBP; NbExp=3; IntAct=EBI-13059134, EBI-3915253;
CC Q13520; P52803: EFNA5; NbExp=3; IntAct=EBI-13059134, EBI-1753674;
CC Q13520; Q9BV81: EMC6; NbExp=3; IntAct=EBI-13059134, EBI-2820492;
CC Q13520; P54849: EMP1; NbExp=3; IntAct=EBI-13059134, EBI-4319440;
CC Q13520; P54852: EMP3; NbExp=3; IntAct=EBI-13059134, EBI-3907816;
CC Q13520; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-13059134, EBI-711490;
CC Q13520; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-13059134, EBI-10976398;
CC Q13520; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-13059134, EBI-11337888;
CC Q13520; Q8N128-2: FAM177A1; NbExp=3; IntAct=EBI-13059134, EBI-12201693;
CC Q13520; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-13059134, EBI-12142299;
CC Q13520; P37268: FDFT1; NbExp=3; IntAct=EBI-13059134, EBI-714550;
CC Q13520; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-13059134, EBI-714482;
CC Q13520; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-13059134, EBI-12175685;
CC Q13520; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-13059134, EBI-713304;
CC Q13520; P01350: GAST; NbExp=3; IntAct=EBI-13059134, EBI-3436637;
CC Q13520; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-13059134, EBI-11991950;
CC Q13520; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-13059134, EBI-6166686;
CC Q13520; P29033: GJB2; NbExp=3; IntAct=EBI-13059134, EBI-3905204;
CC Q13520; Q9NS71: GKN1; NbExp=3; IntAct=EBI-13059134, EBI-3933251;
CC Q13520; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-13059134, EBI-17231387;
CC Q13520; O14653: GOSR2; NbExp=3; IntAct=EBI-13059134, EBI-4401517;
CC Q13520; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-13059134, EBI-11955647;
CC Q13520; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-13059134, EBI-13345167;
CC Q13520; O00155: GPR25; NbExp=3; IntAct=EBI-13059134, EBI-10178951;
CC Q13520; Q14416: GRM2; NbExp=3; IntAct=EBI-13059134, EBI-10232876;
CC Q13520; P04921: GYPC; NbExp=3; IntAct=EBI-13059134, EBI-7797098;
CC Q13520; P09601: HMOX1; NbExp=3; IntAct=EBI-13059134, EBI-2806151;
CC Q13520; P30519: HMOX2; NbExp=3; IntAct=EBI-13059134, EBI-712096;
CC Q13520; P14060: HSD3B1; NbExp=3; IntAct=EBI-13059134, EBI-17426018;
CC Q13520; Q9BUP3-3: HTATIP2; NbExp=3; IntAct=EBI-13059134, EBI-12937691;
CC Q13520; O60725: ICMT; NbExp=3; IntAct=EBI-13059134, EBI-11721771;
CC Q13520; Q01628: IFITM3; NbExp=3; IntAct=EBI-13059134, EBI-7932862;
CC Q13520; P15260: IFNGR1; NbExp=3; IntAct=EBI-13059134, EBI-1030755;
CC Q13520; P24593: IGFBP5; NbExp=3; IntAct=EBI-13059134, EBI-720480;
CC Q13520; O15503: INSIG1; NbExp=3; IntAct=EBI-13059134, EBI-6252425;
CC Q13520; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-13059134, EBI-8503746;
CC Q13520; P11215: ITGAM; NbExp=3; IntAct=EBI-13059134, EBI-2568251;
CC Q13520; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-13059134, EBI-10266796;
CC Q13520; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-13059134, EBI-465137;
CC Q13520; O00180: KCNK1; NbExp=3; IntAct=EBI-13059134, EBI-3914675;
CC Q13520; Q68G75: LEMD1; NbExp=3; IntAct=EBI-13059134, EBI-12268900;
CC Q13520; O15243: LEPROT; NbExp=3; IntAct=EBI-13059134, EBI-15672507;
CC Q13520; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-13059134, EBI-2820517;
CC Q13520; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-13059134, EBI-12133176;
CC Q13520; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-13059134, EBI-12033434;
CC Q13520; P48449: LSS; NbExp=3; IntAct=EBI-13059134, EBI-3930711;
CC Q13520; Q14210: LY6D; NbExp=3; IntAct=EBI-13059134, EBI-1965225;
CC Q13520; P21145: MAL; NbExp=3; IntAct=EBI-13059134, EBI-3932027;
CC Q13520; Q969L2: MAL2; NbExp=3; IntAct=EBI-13059134, EBI-944295;
CC Q13520; Q13021: MALL; NbExp=3; IntAct=EBI-13059134, EBI-750078;
CC Q13520; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-13059134, EBI-10317612;
CC Q13520; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-13059134, EBI-2341610;
CC Q13520; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-13059134, EBI-11956541;
CC Q13520; Q96ES6: MFSD3; NbExp=3; IntAct=EBI-13059134, EBI-745345;
CC Q13520; Q6N075: MFSD5; NbExp=3; IntAct=EBI-13059134, EBI-3920969;
CC Q13520; O43451: MGAM; NbExp=3; IntAct=EBI-13059134, EBI-2829774;
CC Q13520; A0A0C4DFN3: MGLL; NbExp=3; IntAct=EBI-13059134, EBI-12866138;
CC Q13520; P50281: MMP14; NbExp=3; IntAct=EBI-13059134, EBI-992788;
CC Q13520; P11836: MS4A1; NbExp=3; IntAct=EBI-13059134, EBI-2808234;
CC Q13520; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-13059134, EBI-12070086;
CC Q13520; A6NDP7: MYADML2; NbExp=3; IntAct=EBI-13059134, EBI-17641390;
CC Q13520; Q99519: NEU1; NbExp=3; IntAct=EBI-13059134, EBI-721517;
CC Q13520; Q92982: NINJ1; NbExp=3; IntAct=EBI-13059134, EBI-2802124;
CC Q13520; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-13059134, EBI-10317425;
CC Q13520; Q16617: NKG7; NbExp=3; IntAct=EBI-13059134, EBI-3919611;
CC Q13520; Q8N912: NRAC; NbExp=3; IntAct=EBI-13059134, EBI-12051377;
CC Q13520; Q8IXM6: NRM; NbExp=3; IntAct=EBI-13059134, EBI-10262547;
CC Q13520; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-13059134, EBI-1054848;
CC Q13520; Q53FV1: ORMDL2; NbExp=3; IntAct=EBI-13059134, EBI-11075081;
CC Q13520; Q8N138: ORMDL3; NbExp=3; IntAct=EBI-13059134, EBI-721750;
CC Q13520; Q9NUU6: OTULINL; NbExp=3; IntAct=EBI-13059134, EBI-6916492;
CC Q13520; P09466: PAEP; NbExp=3; IntAct=EBI-13059134, EBI-465167;
CC Q13520; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-13059134, EBI-716063;
CC Q13520; I3L0A0: PEDS1-UBE2V1; NbExp=3; IntAct=EBI-13059134, EBI-12213001;
CC Q13520; Q9UBM1-2: PEMT; NbExp=3; IntAct=EBI-13059134, EBI-17513590;
CC Q13520; Q96HA9: PEX11G; NbExp=3; IntAct=EBI-13059134, EBI-17284886;
CC Q13520; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-13059134, EBI-981985;
CC Q13520; Q07326: PIGF; NbExp=3; IntAct=EBI-13059134, EBI-17180304;
CC Q13520; Q9Y342: PLLP; NbExp=3; IntAct=EBI-13059134, EBI-3919291;
CC Q13520; P60201-2: PLP1; NbExp=3; IntAct=EBI-13059134, EBI-12188331;
CC Q13520; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-13059134, EBI-11721828;
CC Q13520; Q59EV6: PPGB; NbExp=3; IntAct=EBI-13059134, EBI-14210385;
CC Q13520; O60831: PRAF2; NbExp=3; IntAct=EBI-13059134, EBI-2506064;
CC Q13520; A5D903: PRB1; NbExp=3; IntAct=EBI-13059134, EBI-10173935;
CC Q13520; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-13059134, EBI-722696;
CC Q13520; P18031: PTPN1; NbExp=3; IntAct=EBI-13059134, EBI-968788;
CC Q13520; P43378: PTPN9; NbExp=3; IntAct=EBI-13059134, EBI-742898;
CC Q13520; Q9NP72: RAB18; NbExp=3; IntAct=EBI-13059134, EBI-722247;
CC Q13520; Q96AA3: RFT1; NbExp=3; IntAct=EBI-13059134, EBI-6269616;
CC Q13520; Q02161-2: RHD; NbExp=3; IntAct=EBI-13059134, EBI-17249212;
CC Q13520; Q9NS64: RPRM; NbExp=3; IntAct=EBI-13059134, EBI-1052363;
CC Q13520; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-13059134, EBI-10244780;
CC Q13520; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-13059134, EBI-8636004;
CC Q13520; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-13059134, EBI-3917235;
CC Q13520; Q969E2: SCAMP4; NbExp=3; IntAct=EBI-13059134, EBI-4403649;
CC Q13520; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-13059134, EBI-2695784;
CC Q13520; O00767: SCD; NbExp=3; IntAct=EBI-13059134, EBI-2684237;
CC Q13520; P11684: SCGB1A1; NbExp=3; IntAct=EBI-13059134, EBI-7797649;
CC Q13520; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-13059134, EBI-8652744;
CC Q13520; O75396: SEC22B; NbExp=3; IntAct=EBI-13059134, EBI-1058865;
CC Q13520; P60059: SEC61G; NbExp=3; IntAct=EBI-13059134, EBI-4402709;
CC Q13520; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-13059134, EBI-9679163;
CC Q13520; O75920: SERF1B; NbExp=3; IntAct=EBI-13059134, EBI-2115181;
CC Q13520; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-13059134, EBI-10329948;
CC Q13520; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-13059134, EBI-749270;
CC Q13520; Q6FHJ7: SFRP4; NbExp=3; IntAct=EBI-13059134, EBI-2854879;
CC Q13520; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-13059134, EBI-2854842;
CC Q13520; O95562: SFT2D2; NbExp=3; IntAct=EBI-13059134, EBI-4402330;
CC Q13520; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-13059134, EBI-355861;
CC Q13520; Q96NB2: SFXN2; NbExp=3; IntAct=EBI-13059134, EBI-6381136;
CC Q13520; A0A1P0AYU5: SFXN3; NbExp=3; IntAct=EBI-13059134, EBI-14193895;
CC Q13520; Q8TD22: SFXN5; NbExp=3; IntAct=EBI-13059134, EBI-17274136;
CC Q13520; Q6ZSM3: SLC16A12; NbExp=3; IntAct=EBI-13059134, EBI-17460560;
CC Q13520; Q7RTY0: SLC16A13; NbExp=3; IntAct=EBI-13059134, EBI-12243266;
CC Q13520; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-13059134, EBI-10281975;
CC Q13520; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-13059134, EBI-8644112;
CC Q13520; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-13059134, EBI-10262251;
CC Q13520; P78382: SLC35A1; NbExp=3; IntAct=EBI-13059134, EBI-12870360;
CC Q13520; P78383: SLC35B1; NbExp=3; IntAct=EBI-13059134, EBI-12147661;
CC Q13520; Q8TB61: SLC35B2; NbExp=3; IntAct=EBI-13059134, EBI-1054782;
CC Q13520; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-13059134, EBI-10281213;
CC Q13520; Q6ICL7: SLC35E4; NbExp=3; IntAct=EBI-13059134, EBI-12867720;
CC Q13520; Q5T1Q4: SLC35F1; NbExp=3; IntAct=EBI-13059134, EBI-13365456;
CC Q13520; Q8N357: SLC35F6; NbExp=3; IntAct=EBI-13059134, EBI-713484;
CC Q13520; Q8TBE7: SLC35G2; NbExp=3; IntAct=EBI-13059134, EBI-727304;
CC Q13520; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-13059134, EBI-9978441;
CC Q13520; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-13059134, EBI-12898013;
CC Q13520; Q92504: SLC39A7; NbExp=3; IntAct=EBI-13059134, EBI-1051105;
CC Q13520; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-13059134, EBI-2823239;
CC Q13520; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-13059134, EBI-12266234;
CC Q13520; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-13059134, EBI-10290130;
CC Q13520; Q9NWF4: SLC52A1; NbExp=3; IntAct=EBI-13059134, EBI-12904614;
CC Q13520; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-13059134, EBI-12889586;
CC Q13520; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-13059134, EBI-3907610;
CC Q13520; P30825: SLC7A1; NbExp=3; IntAct=EBI-13059134, EBI-4289564;
CC Q13520; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-13059134, EBI-13292283;
CC Q13520; Q9UIG8-2: SLCO3A1; NbExp=3; IntAct=EBI-13059134, EBI-13041931;
CC Q13520; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-13059134, EBI-10226799;
CC Q13520; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-13059134, EBI-8640191;
CC Q13520; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-13059134, EBI-12188413;
CC Q13520; Q6UX34: SNORC; NbExp=3; IntAct=EBI-13059134, EBI-11957067;
CC Q13520; Q96JF0-2: ST6GAL2; NbExp=3; IntAct=EBI-13059134, EBI-12908338;
CC Q13520; Q14849: STARD3; NbExp=3; IntAct=EBI-13059134, EBI-9819324;
CC Q13520; P02808: STATH; NbExp=3; IntAct=EBI-13059134, EBI-738687;
CC Q13520; P0DN84: STRIT1; NbExp=3; IntAct=EBI-13059134, EBI-12200293;
CC Q13520; Q86Y82: STX12; NbExp=3; IntAct=EBI-13059134, EBI-2691717;
CC Q13520; P61266: STX1B; NbExp=3; IntAct=EBI-13059134, EBI-9071709;
CC Q13520; Q13277: STX3; NbExp=3; IntAct=EBI-13059134, EBI-1394295;
CC Q13520; Q13190: STX5; NbExp=3; IntAct=EBI-13059134, EBI-714206;
CC Q13520; O43752: STX6; NbExp=3; IntAct=EBI-13059134, EBI-2695795;
CC Q13520; O15400: STX7; NbExp=3; IntAct=EBI-13059134, EBI-3221827;
CC Q13520; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-13059134, EBI-726331;
CC Q13520; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-13059134, EBI-12187159;
CC Q13520; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-13059134, EBI-1049004;
CC Q13520; Q03518: TAP1; NbExp=3; IntAct=EBI-13059134, EBI-747259;
CC Q13520; Q96BZ9: TBC1D20; NbExp=3; IntAct=EBI-13059134, EBI-9254454;
CC Q13520; P02786: TFRC; NbExp=3; IntAct=EBI-13059134, EBI-355727;
CC Q13520; P07204: THBD; NbExp=3; IntAct=EBI-13059134, EBI-941422;
CC Q13520; Q9UPZ6: THSD7A; NbExp=3; IntAct=EBI-13059134, EBI-310962;
CC Q13520; C9JKN6: THSD7B; NbExp=3; IntAct=EBI-13059134, EBI-17192156;
CC Q13520; O14925: TIMM23; NbExp=3; IntAct=EBI-13059134, EBI-1047996;
CC Q13520; Q96CP7: TLCD1; NbExp=3; IntAct=EBI-13059134, EBI-11337932;
CC Q13520; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-13059134, EBI-8644968;
CC Q13520; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-13059134, EBI-12845616;
CC Q13520; Q12893: TMEM115; NbExp=3; IntAct=EBI-13059134, EBI-8633987;
CC Q13520; Q9BXJ8: TMEM120A; NbExp=3; IntAct=EBI-13059134, EBI-727322;
CC Q13520; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-13059134, EBI-10171534;
CC Q13520; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-13059134, EBI-10694905;
CC Q13520; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-13059134, EBI-2844246;
CC Q13520; Q96AN5: TMEM143; NbExp=3; IntAct=EBI-13059134, EBI-13342951;
CC Q13520; Q7Z5S9: TMEM144; NbExp=3; IntAct=EBI-13059134, EBI-12876358;
CC Q13520; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-13059134, EBI-2800360;
CC Q13520; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-13059134, EBI-17684533;
CC Q13520; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-13059134, EBI-741829;
CC Q13520; Q8N511: TMEM199; NbExp=3; IntAct=EBI-13059134, EBI-10265825;
CC Q13520; Q969S6: TMEM203; NbExp=3; IntAct=EBI-13059134, EBI-12274070;
CC Q13520; A2RU14: TMEM218; NbExp=3; IntAct=EBI-13059134, EBI-10173151;
CC Q13520; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-13059134, EBI-347385;
CC Q13520; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-13059134, EBI-12195227;
CC Q13520; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-13059134, EBI-8642211;
CC Q13520; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-13059134, EBI-11528917;
CC Q13520; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-13059134, EBI-10315004;
CC Q13520; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-13059134, EBI-12887458;
CC Q13520; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-13059134, EBI-11956809;
CC Q13520; E9PQX1: TMEM262; NbExp=3; IntAct=EBI-13059134, EBI-17180389;
CC Q13520; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-13059134, EBI-12038591;
CC Q13520; O95807: TMEM50A; NbExp=3; IntAct=EBI-13059134, EBI-12903814;
CC Q13520; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-13059134, EBI-726044;
CC Q13520; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-13059134, EBI-2852148;
CC Q13520; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-13059134, EBI-6656213;
CC Q13520; Q5SWH9: TMEM69; NbExp=3; IntAct=EBI-13059134, EBI-17963363;
CC Q13520; Q96NL1: TMEM74; NbExp=3; IntAct=EBI-13059134, EBI-10292091;
CC Q13520; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-13059134, EBI-2548832;
CC Q13520; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-13059134, EBI-12111910;
CC Q13520; Q71RG4: TMUB2; NbExp=3; IntAct=EBI-13059134, EBI-2820477;
CC Q13520; Q9Y320: TMX2; NbExp=3; IntAct=EBI-13059134, EBI-6447886;
CC Q13520; O14798: TNFRSF10C; NbExp=3; IntAct=EBI-13059134, EBI-717441;
CC Q13520; Q9NS69: TOMM22; NbExp=3; IntAct=EBI-13059134, EBI-1047508;
CC Q13520; Q96B49: TOMM6; NbExp=3; IntAct=EBI-13059134, EBI-10826510;
CC Q13520; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-13059134, EBI-17249488;
CC Q13520; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-13059134, EBI-16746122;
CC Q13520; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-13059134, EBI-12195249;
CC Q13520; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-13059134, EBI-10243654;
CC Q13520; Q8N2K1: UBE2J2; NbExp=3; IntAct=EBI-13059134, EBI-2340110;
CC Q13520; Q8WUN7: UBTD2; NbExp=3; IntAct=EBI-13059134, EBI-12867288;
CC Q13520; O00124: UBXN8; NbExp=3; IntAct=EBI-13059134, EBI-1993850;
CC Q13520; Q53HI1: UNC50; NbExp=3; IntAct=EBI-13059134, EBI-7601760;
CC Q13520; Q86WB7-2: UNC93A; NbExp=3; IntAct=EBI-13059134, EBI-13356252;
CC Q13520; Q9NZ43: USE1; NbExp=3; IntAct=EBI-13059134, EBI-742842;
CC Q13520; P23763-3: VAMP1; NbExp=3; IntAct=EBI-13059134, EBI-12097582;
CC Q13520; P63027: VAMP2; NbExp=3; IntAct=EBI-13059134, EBI-520113;
CC Q13520; Q15836: VAMP3; NbExp=3; IntAct=EBI-13059134, EBI-722343;
CC Q13520; O75379: VAMP4; NbExp=3; IntAct=EBI-13059134, EBI-744953;
CC Q13520; O95183: VAMP5; NbExp=3; IntAct=EBI-13059134, EBI-10191195;
CC Q13520; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-13059134, EBI-1059156;
CC Q13520; O95292: VAPB; NbExp=3; IntAct=EBI-13059134, EBI-1188298;
CC Q13520; Q8N0U8: VKORC1L1; NbExp=3; IntAct=EBI-13059134, EBI-11337915;
CC Q13520; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-13059134, EBI-1055364;
CC Q13520; Q86Y07: VRK2; NbExp=3; IntAct=EBI-13059134, EBI-1207615;
CC Q13520; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-13059134, EBI-12190699;
CC Q13520; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-13059134, EBI-723716;
CC Q13520; O76024: WFS1; NbExp=3; IntAct=EBI-13059134, EBI-720609;
CC Q13520; O95070: YIF1A; NbExp=3; IntAct=EBI-13059134, EBI-2799703;
CC Q13520; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-13059134, EBI-7850136;
CC Q13520; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-13059134, EBI-751204;
CC Q13520; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-13059134, EBI-751253;
CC Q13520; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-13059134, EBI-751210;
CC Q13520; Q8IVQ6: ZDHHC21; NbExp=3; IntAct=EBI-13059134, EBI-2849773;
CC Q13520; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-13059134, EBI-10254561;
CC Q13520; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-13059134, EBI-6427977;
CC Q13520; A0A087WZY1; NbExp=3; IntAct=EBI-13059134, EBI-13387614;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA).
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000305}.
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DR EMBL; U48408; AAB41566.1; -; mRNA.
DR EMBL; AC025154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31798.1; -.
DR RefSeq; NP_001643.2; NM_001652.3.
DR AlphaFoldDB; Q13520; -.
DR SMR; Q13520; -.
DR BioGRID; 106859; 313.
DR IntAct; Q13520; 296.
DR STRING; 9606.ENSP00000477688; -.
DR TCDB; 1.A.8.8.4; the major intrinsic protein (mip) family.
DR iPTMnet; Q13520; -.
DR PhosphoSitePlus; Q13520; -.
DR BioMuta; AQP6; -.
DR DMDM; 212276421; -.
DR PaxDb; Q13520; -.
DR PeptideAtlas; Q13520; -.
DR PRIDE; Q13520; -.
DR Antibodypedia; 26099; 90 antibodies from 23 providers.
DR DNASU; 363; -.
DR Ensembl; ENST00000315520.10; ENSP00000320247.5; ENSG00000086159.13.
DR Ensembl; ENST00000615425.1; ENSP00000477688.1; ENSG00000086159.13.
DR GeneID; 363; -.
DR KEGG; hsa:363; -.
DR MANE-Select; ENST00000315520.10; ENSP00000320247.5; NM_001652.4; NP_001643.2.
DR UCSC; uc001rvr.2; human.
DR CTD; 363; -.
DR DisGeNET; 363; -.
DR GeneCards; AQP6; -.
DR HGNC; HGNC:639; AQP6.
DR HPA; ENSG00000086159; Tissue enriched (kidney).
DR MIM; 601383; gene.
DR neXtProt; NX_Q13520; -.
DR OpenTargets; ENSG00000086159; -.
DR PharmGKB; PA24924; -.
DR VEuPathDB; HostDB:ENSG00000086159; -.
DR eggNOG; KOG0223; Eukaryota.
DR GeneTree; ENSGT00940000161949; -.
DR HOGENOM; CLU_020019_3_3_1; -.
DR InParanoid; Q13520; -.
DR OMA; MAIQVTW; -.
DR OrthoDB; 1152704at2759; -.
DR PhylomeDB; Q13520; -.
DR TreeFam; TF312940; -.
DR PathwayCommons; Q13520; -.
DR Reactome; R-HSA-432047; Passive transport by Aquaporins.
DR SignaLink; Q13520; -.
DR BioGRID-ORCS; 363; 8 hits in 1065 CRISPR screens.
DR GeneWiki; AQP6; -.
DR GenomeRNAi; 363; -.
DR Pharos; Q13520; Tbio.
DR PRO; PR:Q13520; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q13520; protein.
DR Bgee; ENSG00000086159; Expressed in metanephros cortex and 120 other tissues.
DR ExpressionAtlas; Q13520; baseline and differential.
DR Genevisible; Q13520; HS.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015112; F:nitrate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015250; F:water channel activity; IDA:UniProtKB.
DR GO; GO:0015670; P:carbon dioxide transport; IBA:GO_Central.
DR GO; GO:0042476; P:odontogenesis; IEP:UniProtKB.
DR GO; GO:0003097; P:renal water transport; IDA:UniProtKB.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR023254; Aquaporin_6.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR PANTHER; PTHR19139; PTHR19139; 1.
DR PANTHER; PTHR19139:SF113; PTHR19139:SF113; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR02018; AQUAPORIN6.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
DR TIGRFAMs; TIGR00861; MIP; 1.
DR PROSITE; PS00221; MIP; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..282
FT /note="Aquaporin-6"
FT /id="PRO_0000063955"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 260..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 82..84
FT /note="NPA 1"
FT MOTIF 196..198
FT /note="NPA 2"
FT VARIANT 234
FT /note="V -> I (in dbSNP:rs17124220)"
FT /id="VAR_047233"
FT CONFLICT 4..5
FT /note="VE -> EV (in Ref. 1; AAB41566)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="A -> T (in Ref. 1; AAB41566)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="V -> W (in Ref. 1; AAB41566)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="H -> L (in Ref. 1; AAB41566)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="G -> R (in Ref. 1; AAB41566)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 282 AA; 29370 MW; BDA1B3DFCA5C685E CRC64;
MDAVEPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT ALPSVLQIAI
TFNLVTAMAV QVTWKASGAH ANPAVTLAFL VGSHISLPRA VAYVAAQLVG ATVGAALLYG
VMPGDIRETL GINVVRNSVS TGQAVAVELL LTLQLVLCVF ASTDSRQTSG SPATMIGISV
ALGHLIGIHF TGCSMNPARS FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK
TLAQRLAILT GTVEVGTGAG AGAEPLKKES QPGSGAVEME SV
