ID   KDKA_PASMU              Reviewed;         240 AA.
AC   Q9CLD5;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=3-deoxy-D-manno-octulosonic acid kinase;
DE            Short=Kdo kinase;
DE            EC=2.7.1.166;
GN   Name=kdkA; OrderedLocusNames=PM1303;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-
CC       manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH
CC       position. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-
CC         (2->6)-lipid IVA + ADP + H(+); Xref=Rhea:RHEA:28506,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:60364,
CC         ChEBI:CHEBI:61589, ChEBI:CHEBI:456216; EC=2.7.1.166;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/RfaP
CC       family. {ECO:0000305}.
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DR   EMBL; AE004439; AAK03387.1; -; Genomic_DNA.
DR   RefSeq; WP_005734735.1; NC_002663.1.
DR   AlphaFoldDB; Q9CLD5; -.
DR   STRING; 747.DR93_551; -.
DR   EnsemblBacteria; AAK03387; AAK03387; PM1303.
DR   KEGG; pmu:PM1303; -.
DR   PATRIC; fig|272843.6.peg.1314; -.
DR   HOGENOM; CLU_094226_0_0_6; -.
DR   OMA; YYRGGLW; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:UniProtKB-UniRule.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   HAMAP; MF_00521; KDO_kinase; 1.
DR   InterPro; IPR022826; KDO_kinase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Kinase;
KW   Lipopolysaccharide biosynthesis; Membrane; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..240
FT                   /note="3-deoxy-D-manno-octulosonic acid kinase"
FT                   /id="PRO_0000194314"
FT   ACT_SITE        170
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  28159 MW;  79C899B1A5BA9DF0 CRC64;
     MLEFKHKNTF FLFNFKQPKA QQACFFRSSF WKKQARILGS AQGRGVTWFL QTKDLFGVNA
     ALKHYYRGGL WGKINRDYYR FSTLSNARSF AEFSLLKQLH EAGLAVPKPL GACVEKVAFG
     FYRADLLTEK IEHAQDLTVY LQQGKLTEQD WHKVGQLIHQ LHSLQVCHTD LNAHNILVQQ
     RDDGRKFWLI DFDKCAHQLG ERWKSENLNR LHRSFMKEVT RMKIQFSEQD WQALLAGYQA