ID   KDKA_PHODP              Reviewed;         240 AA.
AC   P58551;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=3-deoxy-D-manno-octulosonic acid kinase;
DE            Short=Kdo kinase;
DE            EC=2.7.1.166;
GN   Name=kdkA;
OS   Photobacterium damsela subsp. piscicida (Pasteurella piscicida).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Photobacterium.
OX   NCBI_TaxID=38294;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Rattanachai A., Hirono I., Aoki T.;
RT   "Molecular cloning and characterization of the region encoding for
RT   lipopolysaccharide biosynthesis in Pasteurella piscicida.";
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-
CC       manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH
CC       position. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-
CC         (2->6)-lipid IVA + ADP + H(+); Xref=Rhea:RHEA:28506,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:60364,
CC         ChEBI:CHEBI:61589, ChEBI:CHEBI:456216; EC=2.7.1.166;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/RfaP
CC       family. {ECO:0000305}.
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DR   EMBL; AB074287; BAB72027.1; -; Genomic_DNA.
DR   AlphaFoldDB; P58551; -.
DR   SMR; P58551; -.
DR   UniPathway; UPA00958; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   HAMAP; MF_00521; KDO_kinase; 1.
DR   InterPro; IPR022826; KDO_kinase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Kinase;
KW   Lipopolysaccharide biosynthesis; Membrane; Nucleotide-binding; Transferase.
FT   CHAIN           1..240
FT                   /note="3-deoxy-D-manno-octulosonic acid kinase"
FT                   /id="PRO_0000194315"
FT   ACT_SITE        167
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  27780 MW;  D7C4AE5AF555B1F6 CRC64;
     MQIIQTKQQY ICYNPELLTE TPEMAFSSEF WQQQNKIIGS AQGRGTTWFV QGEKLAMALR
     HYRRGGLFGK LVADSYLFSG WDKTRSVAEF SLLNHLIAHQ VNVPKPVAAR AVRLGWFRYQ
     ADILVEKIAN SRDLVGILGQ ETLSQQVWFD VGAMIKRMHD AGVCHTDLNC HNIILDDHKT
     VWIIDFDKCY RLEGANWQEK NLARLHRSFI KEQGKRGILF NEDNWQWLCK VIRVNGNKGQ