KDPA_CLOP1
ID KDPA_CLOP1 Reviewed; 578 AA.
AC Q0TRT4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Potassium-transporting ATPase potassium-binding subunit {ECO:0000255|HAMAP-Rule:MF_00275};
DE AltName: Full=ATP phosphohydrolase [potassium-transporting] A chain {ECO:0000255|HAMAP-Rule:MF_00275};
DE AltName: Full=Potassium-binding and translocating subunit A {ECO:0000255|HAMAP-Rule:MF_00275};
DE AltName: Full=Potassium-translocating ATPase A chain {ECO:0000255|HAMAP-Rule:MF_00275};
GN Name=kdpA {ECO:0000255|HAMAP-Rule:MF_00275}; OrderedLocusNames=CPF_1210;
OS Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB
OS 6125 / NCTC 8237 / Type A).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=195103;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / S 107 /
RC Type A;
RX PubMed=16825665; DOI=10.1101/gr.5238106;
RA Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA Paulsen I.T.;
RT "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT Clostridium perfringens.";
RL Genome Res. 16:1031-1040(2006).
CC -!- FUNCTION: Part of the high-affinity ATP-driven potassium transport (or
CC Kdp) system, which catalyzes the hydrolysis of ATP coupled with the
CC electrogenic transport of potassium into the cytoplasm. This subunit
CC binds the extracellular potassium ions and delivers the ions to the
CC membrane domain of KdpB through an intramembrane tunnel.
CC {ECO:0000255|HAMAP-Rule:MF_00275}.
CC -!- SUBUNIT: The system is composed of three essential subunits: KdpA, KdpB
CC and KdpC. {ECO:0000255|HAMAP-Rule:MF_00275}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00275};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00275}.
CC -!- SIMILARITY: Belongs to the KdpA family. {ECO:0000255|HAMAP-
CC Rule:MF_00275}.
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DR EMBL; CP000246; ABG83847.1; -; Genomic_DNA.
DR RefSeq; WP_003456394.1; NC_008261.1.
DR AlphaFoldDB; Q0TRT4; -.
DR SMR; Q0TRT4; -.
DR STRING; 195103.CPF_1210; -.
DR PRIDE; Q0TRT4; -.
DR EnsemblBacteria; ABG83847; ABG83847; CPF_1210.
DR GeneID; 29571674; -.
DR KEGG; cpf:CPF_1210; -.
DR eggNOG; COG2060; Bacteria.
DR HOGENOM; CLU_018614_3_0_9; -.
DR OMA; LMMWTEF; -.
DR OrthoDB; 296671at2; -.
DR Proteomes; UP000001823; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0008556; F:P-type potassium transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030955; F:potassium ion binding; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00275; KdpA; 1.
DR InterPro; IPR004623; KdpA.
DR PANTHER; PTHR30607; PTHR30607; 1.
DR Pfam; PF03814; KdpA; 1.
DR PIRSF; PIRSF001294; K_ATPaseA; 1.
DR TIGRFAMs; TIGR00680; kdpA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..578
FT /note="Potassium-transporting ATPase potassium-binding
FT subunit"
FT /id="PRO_1000022217"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
SQ SEQUENCE 578 AA; 61786 MW; 824DA7EC4E18C0CD CRC64;
MSNAILQYSL YLIILVLLAI PLGKYIGKVM NEEKVFLSKL ILPCENFIYK VLGINEEDMD
WKKYSFSVLA FSAVGFIFLF ALNLLQGVLP LNPEGISGSS WDLSFNTTAS FITNTNWQAY
SGESQLSYLT QMLGLTVQNF LSAGVGIAVL FALIRGFTRV NKSGLGNFWR DLTRIVLYLL
VPLSIVLSIL LVSQGTVQNF KPYEEVALLE EIVLDDGNRV TSQIVPQGPA ASQVAIKQLG
TNGGGFFGVN SAHPLENPTA FSNLLEMLSI LLIPAALCFT FGRNIKDKRQ GRAIFIAMFT
LLIIALCIIG VSEANGTPQL AQNGDVNLGY IDQSGGNMEG KESRFGVVGS STWAAFTTAA
SNGSVNSMHD SFTPIGGMVT MLLMQLGEVV FGGVGCGLYG MIAFAIITVF IAGLMVGRTP
EYLGKKIEPY EMKMAMLICL ATPISILIGS ALASINPEIL NSLTNSGAHG FSEILYAYSS
AGGNNGSAFA GLGANTVFIN VSIGLIMLFV RFVPMIATLA IAGSLVKKKK VATSVGTLPT
HNLLFIGLLI FVVLLVGALS FFPALALGPI AEFLQMIA
