AQPC_DICDI
ID AQPC_DICDI Reviewed; 274 AA.
AC Q54V53; Q94495;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Aquaporin C;
DE AltName: Full=Aquaporin-like protein wacA;
DE AltName: Full=Water channel protein A;
GN Name=wacA; ORFNames=DDB_G0280537;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=AX4;
RX PubMed=9305756; DOI=10.1016/s0378-1119(97)00078-4;
RA Flick K.M., Shaulsky G., Loomis W.F.;
RT "The wacA gene of Dictyostelium discoideum is a developmentally regulated
RT member of the MIP family.";
RL Gene 195:127-130(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May form a water-specific channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: First detected after 12 hours of development.
CC Highly expressed after this throughout the development of the fruiting
CC body. Detected exclusively in prespore cells, but not in prestalk
CC cells. {ECO:0000269|PubMed:9305756}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA).
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000305}.
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DR EMBL; U68246; AAB72014.1; -; Genomic_DNA.
DR EMBL; AAFI02000037; EAL67070.1; -; Genomic_DNA.
DR RefSeq; XP_641078.1; XM_635986.1.
DR AlphaFoldDB; Q54V53; -.
DR SMR; Q54V53; -.
DR STRING; 44689.DDB0214915; -.
DR PaxDb; Q54V53; -.
DR EnsemblProtists; EAL67070; EAL67070; DDB_G0280537.
DR GeneID; 8622637; -.
DR KEGG; ddi:DDB_G0280537; -.
DR dictyBase; DDB_G0280537; wacA.
DR eggNOG; KOG0223; Eukaryota.
DR HOGENOM; CLU_020019_3_3_1; -.
DR InParanoid; Q54V53; -.
DR OMA; CRREDIM; -.
DR PhylomeDB; Q54V53; -.
DR Reactome; R-DDI-1237044; Erythrocytes take up carbon dioxide and release oxygen.
DR Reactome; R-DDI-1247673; Erythrocytes take up oxygen and release carbon dioxide.
DR Reactome; R-DDI-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-DDI-432047; Passive transport by Aquaporins.
DR PRO; PR:Q54V53; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR PANTHER; PTHR19139; PTHR19139; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
DR PROSITE; PS00221; MIP; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..274
FT /note="Aquaporin C"
FT /id="PRO_0000327506"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..66
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..154
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..229
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 93..95
FT /note="NPA 1"
FT MOTIF 211..213
FT /note="NPA 2"
FT CONFLICT 179
FT /note="W -> WDPR (in Ref. 1; AAB72014)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 274 AA; 29855 MW; 835794F512DE228A CRC64;
MPFLHLFTPY TNADNTKLIL RVNESRLRLF TRQLLAEFFG TLFVVYIVSG STLAANFAVS
DPIVRVCLIC LVQGFAFAAI IWSISGISGC QLNPAVTVGC VTTGRMGILN GIAFIIFQCV
GALVGAGMMK ASLPTFYERD LSATTLATGV NVARGFFLEM VTTSFLVFVV LGVAVYNEWD
PKISRVAPLA IGCAVIAGVG FLNLFTGGSL NPARSFGPAV FSDTWHRHYI YWFGPICGGI
IAGLFWRIFL SEKVLLIDRP YTDFHRSTYG TATK
