KDPA_PSEAE
ID KDPA_PSEAE Reviewed; 564 AA.
AC P57683;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Potassium-transporting ATPase potassium-binding subunit {ECO:0000255|HAMAP-Rule:MF_00275};
DE AltName: Full=ATP phosphohydrolase [potassium-transporting] A chain {ECO:0000255|HAMAP-Rule:MF_00275};
DE AltName: Full=Potassium-binding and translocating subunit A {ECO:0000255|HAMAP-Rule:MF_00275};
DE AltName: Full=Potassium-translocating ATPase A chain {ECO:0000255|HAMAP-Rule:MF_00275};
GN Name=kdpA {ECO:0000255|HAMAP-Rule:MF_00275}; OrderedLocusNames=PA1633;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Part of the high-affinity ATP-driven potassium transport (or
CC Kdp) system, which catalyzes the hydrolysis of ATP coupled with the
CC electrogenic transport of potassium into the cytoplasm. This subunit
CC binds the periplasmic potassium ions and delivers the ions to the
CC membrane domain of KdpB through an intramembrane tunnel.
CC {ECO:0000255|HAMAP-Rule:MF_00275}.
CC -!- SUBUNIT: The system is composed of three essential subunits: KdpA, KdpB
CC and KdpC. {ECO:0000255|HAMAP-Rule:MF_00275}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00275}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00275}.
CC -!- SIMILARITY: Belongs to the KdpA family. {ECO:0000255|HAMAP-
CC Rule:MF_00275}.
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DR EMBL; AE004091; AAG05022.1; -; Genomic_DNA.
DR PIR; H83440; H83440.
DR RefSeq; NP_250324.1; NC_002516.2.
DR RefSeq; WP_003097846.1; NZ_QZGE01000003.1.
DR AlphaFoldDB; P57683; -.
DR SMR; P57683; -.
DR STRING; 287.DR97_256; -.
DR PaxDb; P57683; -.
DR EnsemblBacteria; AAG05022; AAG05022; PA1633.
DR GeneID; 883055; -.
DR KEGG; pae:PA1633; -.
DR PATRIC; fig|208964.12.peg.1693; -.
DR PseudoCAP; PA1633; -.
DR HOGENOM; CLU_018614_3_0_6; -.
DR InParanoid; P57683; -.
DR OMA; AWSNLFE; -.
DR PhylomeDB; P57683; -.
DR BioCyc; PAER208964:G1FZ6-1663-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008556; F:P-type potassium transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030955; F:potassium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR HAMAP; MF_00275; KdpA; 1.
DR InterPro; IPR004623; KdpA.
DR PANTHER; PTHR30607; PTHR30607; 1.
DR Pfam; PF03814; KdpA; 1.
DR PIRSF; PIRSF001294; K_ATPaseA; 1.
DR TIGRFAMs; TIGR00680; kdpA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..564
FT /note="Potassium-transporting ATPase potassium-binding
FT subunit"
FT /id="PRO_0000166513"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00275"
SQ SEQUENCE 564 AA; 59935 MW; A359E0E4F005A4B4 CRC64;
MNSHEILLIL AFFALVLVPA PFLGRYCFKV MEGQRNLLSA PLAPLERVCY RLFGVDPASE
QDWKTYTLAL LAFNLAGLVL LFSILMLQGS LPLNPQHLPG LEWTLAFNTA VSFVTNTNWQ
AYSGEASLSY FSQMVGLTVQ NFVSAAVGLC VLVALARGIS RRSTRQLGNF WVDLTRGTLY
VLLPLCLLLA LLLVWQGVPQ TFFDYVHATT LQGAEQTIPL GPAASQIAIK QLGTNGGGFF
GVNSTHPFEN PSAWSNLFEV ASIILIPAAL VFTFGHYVKD LRQSRAILGC MLLLFCLGLG
LSLWAEYQPN PALAQLPIEQ GAPMEGKESR FGTAASMLWA ITTTAASNGS VNAMHDSLSP
LGGMLPLLNM MLGEVIFGGV GAGLYGMLLF VLIAVFLAGL MVGRTPEYLG KKLEAKEVRL
LVFTLLVMPV GVLVLGAIAA SLPGPASAVT NPGPHGFSQL LYAYTSGSAN NGSAFAGFGA
NTPFHNLMIG LAMLIGRFGY ILPILAIAGS LAAKKASPVG PNSFPTHGPL FVSLLTVTIL
LVGGLTFLPT LALGPIAEQL SLGF
