ID   KDPA_STAAU              Reviewed;         307 AA.
AC   P0A058; Q99QS8; Q9LC50; Q9XBA7;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Potassium-transporting ATPase potassium-binding subunit {ECO:0000250|UniProtKB:P03959};
DE   AltName: Full=ATP phosphohydrolase [potassium-transporting] A chain {ECO:0000250|UniProtKB:P03959};
DE   AltName: Full=Potassium-binding and translocating subunit A {ECO:0000250|UniProtKB:P03959};
DE   AltName: Full=Potassium-translocating ATPase A chain {ECO:0000250|UniProtKB:P03959};
DE   Flags: Fragment;
GN   Name=kdpA {ECO:0000250|UniProtKB:P03959}; Synonyms=kdpA2;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NU3-1;
RX   PubMed=10754251; DOI=10.1111/j.1574-6968.2000.tb09065.x;
RA   Horii T., Yokoyama K., Barua S., Odagiri T., Futamura N., Hasegawa T.,
RA   Ohta M.;
RT   "The staphylokinase gene is located in the structural gene encoding N-
RT   acetylmuramyl-L-alanine amidase in methicillin-resistant Staphylococcus
RT   aureus.";
RL   FEMS Microbiol. Lett. 185:221-224(2000).
CC   -!- FUNCTION: Part of the high-affinity ATP-driven potassium transport (or
CC       Kdp) system, which catalyzes the hydrolysis of ATP coupled with the
CC       electrogenic transport of potassium into the cytoplasm. This subunit
CC       binds the extracellular potassium ions and delivers the ions to the
CC       membrane domain of KdpB through an intramembrane tunnel.
CC       {ECO:0000250|UniProtKB:P03959}.
CC   -!- SUBUNIT: The system is composed of three essential subunits: KdpA, KdpB
CC       and KdpC. {ECO:0000250|UniProtKB:P03959}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P03959};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P03959}.
CC   -!- SIMILARITY: Belongs to the KdpA family. {ECO:0000250|UniProtKB:P03959}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA95007.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB033232; BAA95007.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; P0A058; -.
DR   SMR; P0A058; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008556; F:P-type potassium transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004623; KdpA.
DR   PANTHER; PTHR30607; PTHR30607; 1.
DR   Pfam; PF03814; KdpA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           <1..307
FT                   /note="Potassium-transporting ATPase potassium-binding
FT                   subunit"
FT                   /id="PRO_0000166532"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   307 AA;  33390 MW;  CFFD43793DBC2685 CRC64;
     ALSMMLIPGS LVFLFGRMLK TKLQIHPHAI MIFVAMFVMF IGFLVTCLYF EFAGNPVLHH
     LGIAGGNMEG KETRFGIGLS ALFTTITTAF TTGTVNNMHD SLTPLGGMVP MVLMMLNAVF
     GGEGVGLMNM LIYVMLTVFI CSLMIGKTPS YLGMKIEGKE MKLIALSFLV HPLLILVFSA
     LAFIVPGASD ALTNPQFHGV SQVLYEFTSS SANNGSGFEG LGDNTVFWNI STGIVMLLAR
     YIPIVLQILI VSSLVNKKTY QQHTQDVPIN NLFFSSVLII FIILLSGLTF LPDLMLGPIG
     EQLLLHA