ID   AQPZ_FLAJO              Reviewed;          79 AA.
AC   Q7WVD3;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Aquaporin Z;
DE   Flags: Fragment;
GN   Name=aqpZ; Synonyms=fjo22;
OS   Flavobacterium johnsoniae (Cytophaga johnsonae).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   McBride M.J.;
RT   "Cloning and characterization of the Flavobacterium johnsoniae gliding
RT   motility gene gldI.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Channel that permits osmotically driven movement of water in
CC       both directions. It is involved in the osmoregulation and in the
CC       maintenance of cell turgor during volume expansion in rapidly growing
CC       cells. It mediates rapid entry or exit of water in response to abrupt
CC       changes in osmolarity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000305}.
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DR   EMBL; AF527792; AAQ02336.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7WVD3; -.
DR   SMR; Q7WVD3; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR45724; PTHR45724; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..>79
FT                   /note="Aquaporin Z"
FT                   /id="PRO_0000063988"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           62..64
FT                   /note="NPA 1"
FT   SITE            19
FT                   /note="Involved in tetramerization or stability of the
FT                   tetramer"
FT                   /evidence="ECO:0000250"
FT   SITE            42
FT                   /note="Selectivity filter"
FT                   /evidence="ECO:0000250"
FT   NON_TER         79
SQ   SEQUENCE   79 AA;  8159 MW;  7BB7B67806246ADC CRC64;
     MKKLFAEFFG TYWLVFGGCG SAVFAAGYPT LGIGFAGVAL AFGLTVLTMA YAVGHISGGH
     FNPAVSFGLW AGGRFSAKD