ID   AQP_ENCHE               Reviewed;         251 AA.
AC   Q1M1A0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Aquaporin;
GN   Name=AQP;
OS   Encephalitozoon hellem (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=27973;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wasson K., Barry P.A.;
RT   "Role for aquaporins in encephalitozoonosis.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Water channel required to facilitate the transport of water
CC       across membranes. Involved in osmotolerance (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC       membrane-spanning domains and a pore-forming loop with the signature
CC       motif Asn-Pro-Ala (NPA). In microsporidia, the second signature motif
CC       differs slightly and is Asn-Pro-Gly (NPG).
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000305}.
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DR   EMBL; AY325888; AAQ91842.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1M1A0; -.
DR   SMR; Q1M1A0; -.
DR   VEuPathDB; MicrosporidiaDB:EHEL_070710; -.
DR   VEuPathDB; MicrosporidiaDB:KMI_08g12930; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR19139; PTHR19139; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..251
FT                   /note="Aquaporin"
FT                   /id="PRO_0000385185"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..42
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..133
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..224
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOTIF           69..71
FT                   /note="NPA"
FT   MOTIF           206..208
FT                   /note="NPG"
SQ   SEQUENCE   251 AA;  26695 MW;  28C0FA54E789C853 CRC64;
     MAGETLRKIQ SLLGEMVASF IFGFAVYSAI LGSTIAQQPA AKVIIGLTVG FSAIGIIYSF
     SDVTIAHFNP AITLAAILTG KMGILCGLGY MLAQCVGFIL AVCALLVCSP VGYKETLNVI
     RPAPAPFGAD NLNVFFTEFF LTAILVHIAF AVAVNPYRPK VDTDGKFVDP DEKEPVDRRI
     TAPLCIGLTL GFLAFMGLVT SGGAFNPGLT LAPVIMSNTW QHFWLYLGAQ YLGGLVGGLL
     QVFVLYKLSS N