ID   AQP_HAEIX               Reviewed;         251 AA.
AC   Q25074;
DT   03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Aquaporin;
DE   AltName: Full=BfWC1;
DE   AltName: Full=Water channel 1;
OS   Haematobia irritans exigua (Buffalo fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Haematobia.
OX   NCBI_TaxID=34678;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10469254; DOI=10.1046/j.1365-2583.1999.83122.x;
RA   Elvin C.M., Bunch R., Liyou N.E., Pearson R.D., Gough J., Drinkwater R.D.;
RT   "Molecular cloning and expression in Escherichia coli of an aquaporin-like
RT   gene from adult buffalo fly (Haematobia irritans exigua).";
RL   Insect Mol. Biol. 8:369-380(1999).
CC   -!- FUNCTION: Forms a water-specific channel. {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC       membrane-spanning domains and a pore-forming loop with the signature
CC       motif Asn-Pro-Ala (NPA).
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000305}.
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DR   EMBL; U51638; AAA96783.1; -; mRNA.
DR   AlphaFoldDB; Q25074; -.
DR   SMR; Q25074; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   CDD; cd00333; MIP; 1.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR19139; PTHR19139; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   TIGRFAMs; TIGR00861; MIP; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..251
FT                   /note="Aquaporin"
FT                   /id="PRO_0000063977"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..56
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..138
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOTIF           81..83
FT                   /note="NPA 1"
FT   MOTIF           198..200
FT                   /note="NPA 2"
SQ   SEQUENCE   251 AA;  26166 MW;  CC158C8BC378DF79 CRC64;
     MVEKLDMSAV VGVKDITDNK KIWRQLMAEL IGTFFLVVIG VGSCTGGSEW SPSIPQIAFT
     FGLTVATLAQ AIGHISGCHI NPAVTVGFLI VGEMSIIKSV LYIAVQCVGA IAGAAVIKVG
     VSEAVSGLDL GVSSFSSTLT VGQAVLIEAL ITFILVVVVK GVSDPGRTDI KGSAPLAVGL
     SIAAGHLCAI KLTGASMNPA RSFGPAVVQN MWIDHWVYWV GPIVGAIVAA LLYKFVFKVR
     KGDDEANSYD F