KDPE_MYCTO
ID KDPE_MYCTO Reviewed; 226 AA.
AC P9WGN0; L0T8E7; P96373; Q7D8Z1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Transcriptional regulatory protein KdpE;
GN Name=kdpE; OrderedLocusNames=MT1056;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Member of the two-component regulatory system KdpD/KdpE
CC involved in the regulation of the kdp operon. Upon phosphorylation by
CC KdpD, functions as a transcription regulator by direct binding to
CC promoter regions of target genes to positively regulate their
CC expression. {ECO:0000250|UniProtKB:P9WGN1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by KdpD. {ECO:0000250|UniProtKB:P9WGN1}.
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DR EMBL; AE000516; AAK45308.1; -; Genomic_DNA.
DR PIR; F70623; F70623.
DR RefSeq; WP_003405305.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WGN0; -.
DR SMR; P9WGN0; -.
DR EnsemblBacteria; AAK45308; AAK45308; MT1056.
DR GeneID; 45424999; -.
DR KEGG; mtc:MT1056; -.
DR PATRIC; fig|83331.31.peg.1134; -.
DR HOGENOM; CLU_000445_30_8_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..226
FT /note="Transcriptional regulatory protein KdpE"
FT /id="PRO_0000428333"
FT DOMAIN 3..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 127..226
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 52
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000250|UniProtKB:P9WGN1,
FT ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 226 AA; 24741 MW; 68BE8DDC38AED423 CRC64;
MTLVLVIDDE PQILRALRIN LTVRGYQVIT ASTGAGALRA AAEHPPDVVI LDLGLPDMSG
IDVLGGLRGW LTAPVIVLSA RTDSSDKVQA LDAGADDYVT KPFGMDEFLA RLRAAVRRNT
AAAELEQPVI ETDSFTVDLA GKKVIKDGAE VHLTPTEWGM LEMLARNRGK LVGRGELLKE
VWGPAYATET HYLRVYLAQL RRKLEDDPSH PKHLLTESGM GYRFEA
