KDPF_HALS3
ID KDPF_HALS3 Reviewed; 29 AA.
AC B0R9L8;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Potassium-transporting ATPase KdpF subunit {ECO:0000250|UniProtKB:P36937};
DE AltName: Full=ATP phosphohydrolase [potassium-transporting] F chain {ECO:0000250|UniProtKB:P36937};
DE AltName: Full=Potassium-binding and translocating subunit F {ECO:0000250|UniProtKB:P36937};
DE AltName: Full=Potassium-translocating ATPase F chain {ECO:0000250|UniProtKB:P36937};
GN Name=kdpF {ECO:0000312|EMBL:CAP15445.1};
GN OrderedLocusNames=OE_5051A1F {ECO:0000312|EMBL:CAP15445.1};
OS Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OG Plasmid PHS3 {ECO:0000312|EMBL:CAP15445.1}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=478009;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29341 / DSM 671 / R1;
RX PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT R1 compared to that of strain NRC-1.";
RL Genomics 91:335-346(2008).
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 29341 / DSM 671 / R1;
RX PubMed=18633573; DOI=10.1007/s00792-008-0177-3;
RA Strahl H., Greie J.C.;
RT "The extremely halophilic archaeon Halobacterium salinarum R1 responds to
RT potassium limitation by expression of the K+-transporting KdpFABC P-type
RT ATPase and by a decrease in intracellular K+.";
RL Extremophiles 12:741-752(2008).
RN [3]
RP INDUCTION.
RC STRAIN=ATCC 29341 / DSM 671 / R1;
RX PubMed=21947979; DOI=10.1007/s00792-011-0395-y;
RA Kixmueller D., Strahl H., Wende A., Greie J.C.;
RT "Archaeal transcriptional regulation of the prokaryotic KdpFABC complex
RT mediating K(+) uptake in H. salinarum.";
RL Extremophiles 15:643-652(2011).
RN [4]
RP FUNCTION, AND INDUCTION.
RC STRAIN=ATCC 29341 / DSM 671 / R1;
RX PubMed=23757278; DOI=10.1111/j.1758-2229.2012.00326.x;
RA Kixmueller D., Greie J.C.;
RT "An ATP-driven potassium pump promotes long-term survival of Halobacterium
RT salinarum within salt crystals.";
RL Environ. Microbiol. Rep. 4:234-241(2012).
CC -!- FUNCTION: Part of the high-affinity ATP-driven potassium transport (or
CC Kdp) system, which catalyzes the hydrolysis of ATP coupled with the
CC electrogenic transport of potassium into the cytoplasm. This subunit
CC may be involved in stabilization of the complex (By similarity). The
CC Kdp system is essential for growth under K(+) limitation, and for
CC survival under desiccation and salt crystal inclusion (PubMed:18633573,
CC PubMed:23757278). {ECO:0000250|UniProtKB:P36937,
CC ECO:0000269|PubMed:18633573, ECO:0000269|PubMed:23757278}.
CC -!- SUBUNIT: The system is composed of three essential subunits: KdpA, KdpB
CC and KdpC. The complex also contains KdpF, a small non-essential
CC subunit. {ECO:0000250|UniProtKB:P36937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Up-regulated in response to K(+) limitation
CC (PubMed:18633573, PubMed:21947979). Induced under desiccating
CC conditions (PubMed:23757278). {ECO:0000269|PubMed:18633573,
CC ECO:0000269|PubMed:21947979, ECO:0000269|PubMed:23757278}.
CC -!- DISRUPTION PHENOTYPE: kdpFABCQ and kdpFABC deletion strains are only
CC able to grow in the presence of K(+) concentrations above 60 uM.
CC {ECO:0000269|PubMed:18633573}.
CC -!- SIMILARITY: Belongs to the KdpF family. {ECO:0000305}.
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DR EMBL; AM774418; CAP15445.1; -; Genomic_DNA.
DR RefSeq; WP_012289616.1; NC_010368.1.
DR AlphaFoldDB; B0R9L8; -.
DR SMR; B0R9L8; -.
DR EnsemblBacteria; CAP15445; CAP15445; OE_5051A1F.
DR GeneID; 5954984; -.
DR GeneID; 62888113; -.
DR KEGG; hsl:OE_5051A1F; -.
DR HOGENOM; CLU_221466_0_0_2; -.
DR Proteomes; UP000001321; Plasmid PHS3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008556; F:P-type potassium transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0043462; P:regulation of ATP-dependent activity; IEA:InterPro.
DR InterPro; IPR011726; KdpF.
DR Pfam; PF09604; Potass_KdpF; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Plasmid; Potassium;
KW Potassium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..29
FT /note="Potassium-transporting ATPase KdpF subunit"
FT /id="PRO_0000433792"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 29 AA; 3222 MW; D2032E71E511B2DB CRC64;
MLIGEAVLAV VTVAVVAYLT YVMMYPTRF
