ID   KDPQ_HALS3              Reviewed;         272 AA.
AC   B0R9M2;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Probable Kdp system regulatory protein KdpQ {ECO:0000305};
GN   Name=kdpQ {ECO:0000303|PubMed:18633573};
GN   Synonyms=cat3 {ECO:0000303|PubMed:18633573};
GN   OrderedLocusNames=OE_5055F {ECO:0000312|EMBL:CAP15449.1};
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OG   Plasmid PHS3 {ECO:0000312|EMBL:CAP15449.1}.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18633573; DOI=10.1007/s00792-008-0177-3;
RA   Strahl H., Greie J.C.;
RT   "The extremely halophilic archaeon Halobacterium salinarum R1 responds to
RT   potassium limitation by expression of the K+-transporting KdpFABC P-type
RT   ATPase and by a decrease in intracellular K+.";
RL   Extremophiles 12:741-752(2008).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=21947979; DOI=10.1007/s00792-011-0395-y;
RA   Kixmueller D., Strahl H., Wende A., Greie J.C.;
RT   "Archaeal transcriptional regulation of the prokaryotic KdpFABC complex
RT   mediating K(+) uptake in H. salinarum.";
RL   Extremophiles 15:643-652(2011).
RN   [4]
RP   INDUCTION.
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=23757278; DOI=10.1111/j.1758-2229.2012.00326.x;
RA   Kixmueller D., Greie J.C.;
RT   "An ATP-driven potassium pump promotes long-term survival of Halobacterium
RT   salinarum within salt crystals.";
RL   Environ. Microbiol. Rep. 4:234-241(2012).
CC   -!- FUNCTION: Has probably an essential function in the transcriptional
CC       regulation of the kdpFABCQ operon. {ECO:0000269|PubMed:18633573}.
CC   -!- INDUCTION: Up-regulated in response to K(+) limitation
CC       (PubMed:18633573, PubMed:21947979). Induced under desiccating
CC       conditions (PubMed:23757278). {ECO:0000269|PubMed:18633573,
CC       ECO:0000269|PubMed:21947979, ECO:0000269|PubMed:23757278}.
CC   -!- DISRUPTION PHENOTYPE: kdpFABCQ deletion strains are only able to grow
CC       in the presence of K(+) concentrations above 60 uM.
CC       {ECO:0000269|PubMed:18633573}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; AM774418; CAP15449.1; -; Genomic_DNA.
DR   RefSeq; WP_010904059.1; NC_010368.1.
DR   AlphaFoldDB; B0R9M2; -.
DR   SMR; B0R9M2; -.
DR   EnsemblBacteria; CAP15449; CAP15449; OE_5055F.
DR   GeneID; 5954968; -.
DR   GeneID; 62888117; -.
DR   KEGG; hsl:OE_5055F; -.
DR   HOGENOM; CLU_082639_0_0_2; -.
DR   OMA; GWHGRPR; -.
DR   Proteomes; UP000001321; Plasmid PHS3.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
PE   2: Evidence at transcript level;
KW   Plasmid; Stress response.
FT   CHAIN           1..272
FT                   /note="Probable Kdp system regulatory protein KdpQ"
FT                   /id="PRO_0000433793"
SQ   SEQUENCE   272 AA;  29792 MW;  209AB688FDA3D673 CRC64;
     MSARNETGYE RVLVPVGDKS DPNMLTELSS ILVDPRRGAV RFTHVTTDRS FVGSQENWRT
     GSDSVAESQH TLREEGIEST GTIRTASSAL DGILEEAEEY EADAILIGWT DKDSVSSLVD
     KLLRKAGCDV IVFSADRDPI DTDSILVPVV VKPDANRLQM LAIMSQRTGA SITFTYVTGD
     EGTDEEGRGL LDQSAERLAE YGVQAETELK SASSAVDALG QLSEDYDVMV IGTSRGWWLR
     KTLFGRKTDK IAQEAQCSLL MHKWQGEVPP ES