ID   KDSA_CHLP6              Reviewed;         269 AA.
AC   Q46225; F0T5I5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase;
DE            EC=2.5.1.55;
DE   AltName: Full=3-deoxy-D-manno-octulosonic acid 8-phosphate synthase;
DE   AltName: Full=KDO-8-phosphate synthase;
DE            Short=KDO 8-P synthase;
DE            Short=KDOPS;
DE   AltName: Full=Phospho-2-dehydro-3-deoxyoctonate aldolase;
GN   Name=kdsA; OrderedLocusNames=CPSIT_0024, G5O_0030;
OS   Chlamydophila psittaci (strain ATCC VR-125 / 6BC) (Chlamydia psittaci).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=331636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-125 / 6BC;
RX   PubMed=9063447; DOI=10.1111/j.1432-1033.1997.00066.x;
RA   Brabetz W., Brade H.;
RT   "Molecular cloning, sequence analysis and functional characterization of
RT   the gene kdsA, encoding 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase
RT   of Chlamydia psittaci 6BC.";
RL   Eur. J. Biochem. 244:66-73(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-125 / 6BC;
RX   PubMed=21441521; DOI=10.1128/jb.00236-11;
RA   Voigt A., Schofl G., Heidrich A., Sachse K., Saluz H.P.;
RT   "Full-length de novo sequence of the Chlamydophila psittaci type strain,
RT   6BC.";
RL   J. Bacteriol. 193:2662-2663(2011).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-125 / 6BC;
RX   PubMed=21622741; DOI=10.1128/jb.05277-11;
RA   Grinblat-Huse V., Drabek E.F., Creasy H.H., Daugherty S.C., Jones K.M.,
RA   Santana-Cruz I., Tallon L.J., Read T.D., Hatch T.P., Bavoil P., Myers G.S.;
RT   "Genome sequences of the zoonotic pathogens Chlamydia psittaci 6BC and
RT   Cal10.";
RL   J. Bacteriol. 193:4039-4040(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-
CC         alpha-D-manno-2-octulosonate-8-phosphate + phosphate;
CC         Xref=Rhea:RHEA:14053, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57693, ChEBI:CHEBI:58702, ChEBI:CHEBI:85985; EC=2.5.1.55;
CC   -!- PATHWAY: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate
CC       biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate:
CC       step 2/3.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the KdsA family. {ECO:0000305}.
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DR   EMBL; Z50747; CAA90622.1; -; Genomic_DNA.
DR   EMBL; CP002549; ADZ18169.1; -; Genomic_DNA.
DR   EMBL; CP002586; AEB55044.1; -; Genomic_DNA.
DR   RefSeq; WP_006342696.1; NC_017287.1.
DR   AlphaFoldDB; Q46225; -.
DR   SMR; Q46225; -.
DR   GeneID; 12242289; -.
DR   KEGG; chb:G5O_0030; -.
DR   KEGG; chp:CPSIT_0024; -.
DR   PATRIC; fig|331636.3.peg.23; -.
DR   HOGENOM; CLU_036666_0_0_0; -.
DR   OMA; FRGIPTM; -.
DR   BRENDA; 2.5.1.55; 1312.
DR   UniPathway; UPA00030; -.
DR   UniPathway; UPA00357; UER00474.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008676; F:3-deoxy-8-phosphooctulonate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019294; P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00056; KDO8P_synth; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006269; KDO8P_synthase.
DR   PANTHER; PTHR21057; PTHR21057; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   TIGRFAMs; TIGR01362; KDO8P_synth; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lipopolysaccharide biosynthesis; Transferase.
FT   CHAIN           1..269
FT                   /note="2-dehydro-3-deoxyphosphooctonate aldolase"
FT                   /id="PRO_0000187118"
SQ   SEQUENCE   269 AA;  29382 MW;  55A4F40ABFB7ADE4 CRC64;
     MFSDKMILIA GPCVIEEEET TLEIASKIQE IVAPYTDHIH WIFKSSYDKA NRSSINSYRG
     PGLQEGLRIL SKVKQTFGVE ILTDVHSPEE ARAAAEVCDI LQIPAFLCRQ TDLLVAAAET
     HAVINIKKGQ FLSPWDMQGP VDKVLSTGNS KIILTERGCS FGYNNLVSDM RSIAVLSKMG
     FPVVFDGTHS VQLPGGLKTH SGGQTEFIPT LTRAALAAGA HGLFIETHMN PAIAKSDAAS
     MLSLKTFEAL LPIWNQLYQC VRSFEMAAV