AR13A_MOUSE
ID AR13A_MOUSE Reviewed; 372 AA.
AC Q9D416; Q497J4;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=ADP-ribosylation factor-like protein 13A;
GN Name=Arl13a; Synonyms=Arl13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. {ECO:0000305}.
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DR EMBL; AK016872; BAB30477.1; -; mRNA.
DR EMBL; AL671915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL672215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100522; AAI00523.1; -; mRNA.
DR CCDS; CCDS53182.1; -.
DR RefSeq; NP_083223.1; NM_028947.1.
DR AlphaFoldDB; Q9D416; -.
DR SMR; Q9D416; -.
DR STRING; 10090.ENSMUSP00000064416; -.
DR iPTMnet; Q9D416; -.
DR PhosphoSitePlus; Q9D416; -.
DR PaxDb; Q9D416; -.
DR PRIDE; Q9D416; -.
DR ProteomicsDB; 273916; -.
DR Antibodypedia; 51206; 36 antibodies from 10 providers.
DR Ensembl; ENSMUST00000064476; ENSMUSP00000064416; ENSMUSG00000052549.
DR GeneID; 74448; -.
DR KEGG; mmu:74448; -.
DR UCSC; uc009ufp.1; mouse.
DR CTD; 392509; -.
DR MGI; MGI:1921698; Arl13a.
DR VEuPathDB; HostDB:ENSMUSG00000052549; -.
DR eggNOG; KOG0073; Eukaryota.
DR GeneTree; ENSGT00940000161284; -.
DR HOGENOM; CLU_040729_3_1_1; -.
DR InParanoid; Q9D416; -.
DR OMA; KGREIWP; -.
DR OrthoDB; 732329at2759; -.
DR PhylomeDB; Q9D416; -.
DR TreeFam; TF105476; -.
DR BioGRID-ORCS; 74448; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Arl13a; mouse.
DR PRO; PR:Q9D416; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D416; protein.
DR Bgee; ENSMUSG00000052549; Expressed in spermatid and 4 other tissues.
DR Genevisible; Q9D416; MM.
DR GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0097730; C:non-motile cilium; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR GO; GO:0097500; P:receptor localization to non-motile cilium; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..372
FT /note="ADP-ribosylation factor-like protein 13A"
FT /id="PRO_0000284146"
FT BINDING 28..35
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 71..75
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 130..133
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT CONFLICT 144
FT /note="I -> M (in Ref. 3; AAI00523)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 43463 MW; 11EFD39B1AF573B1 CRC64;
MFRLLTACWS RQKTTEEKQR NVTIIVIGLD NSGKSRLIEA FQRLIPSKMH KEMRPTQTTL
LLDDYQVSIY DLTGDVKGRE KWSSYYAQAH GLIFVVDSSD IARIQEVKII LTRIMFDKRV
SGKPILILAN KQDKKNALLP CDIIEYLLLE RLVNETRSMC RVEPCSTIKR IPKRQQKPIV
VGLRWLLAAI GDQYSELYTR QQIPNMSIST SKNIRGCGER CLSDSLPNRV RHSNRQHFDK
RQHMEHRQHV EQRHFEKRQH FEARQRLIQR SLDARPLKPI LQKDGFRIRP KKNMSVTFAL
DVIMEEGECS RKIGAPTISK PCSSQCYDTK TPDPSVDVSL FKAHKPKKRI ETWDTEEMFL
EDPREETFHS CD
