ID   KDSA_PEA                Reviewed;         290 AA.
AC   O50044;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase;
DE            EC=2.5.1.55 {ECO:0000250|UniProtKB:Q9AV97};
DE   AltName: Full=3-deoxy-D-manno-octulosonic acid 8-phosphate synthase;
DE   AltName: Full=KDO-8-phosphate synthase;
DE            Short=KDO 8-P synthase;
DE            Short=KDOPS;
DE   AltName: Full=Phospho-2-dehydro-3-deoxyoctonate aldolase;
GN   Name=KDSA;
OS   Pisum sativum (Garden pea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX   NCBI_TaxID=3888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Die kleine Rheinlaenderin;
RX   PubMed=11219578; DOI=10.1007/s004250000459;
RA   Brabetz W., Wolter F.P., Brade H.;
RT   "A cDNA encoding 3-deoxy-D-manno-oct-2-ulosonate-8-phosphate synthase of
RT   Pisum sativum L. (pea) functionally complements a kdsA mutant of the Gram-
RT   negative bacterium Salmonella enterica.";
RL   Planta 212:136-143(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-
CC         alpha-D-manno-2-octulosonate-8-phosphate + phosphate;
CC         Xref=Rhea:RHEA:14053, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57693, ChEBI:CHEBI:58702, ChEBI:CHEBI:85985; EC=2.5.1.55;
CC         Evidence={ECO:0000250|UniProtKB:Q9AV97};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KdsA family. {ECO:0000305}.
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DR   EMBL; Y14273; CAA74645.1; -; mRNA.
DR   EMBL; Y14272; CAA74644.1; -; mRNA.
DR   PIR; T06816; T06816.
DR   AlphaFoldDB; O50044; -.
DR   SMR; O50044; -.
DR   EnsemblPlants; Psat3g099560.1; Psat3g099560.1.cds; Psat3g099560.
DR   Gramene; Psat3g099560.1; Psat3g099560.1.cds; Psat3g099560.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008676; F:3-deoxy-8-phosphooctulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00056; KDO8P_synth; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006269; KDO8P_synthase.
DR   PANTHER; PTHR21057; PTHR21057; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   TIGRFAMs; TIGR01362; KDO8P_synth; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Transferase.
FT   CHAIN           1..290
FT                   /note="2-dehydro-3-deoxyphosphooctonate aldolase"
FT                   /id="PRO_0000187180"
SQ   SEQUENCE   290 AA;  31723 MW;  56F37C3779FBF398 CRC64;
     MDPSVLLYNQ LKAADPFFLL AGPNVIESEE HIMRMAKHIK TISSKFGIPL IFKSSFDKAN
     RTSSKSFRGP GIVEGLKILE KVKIAYDIPI VTDVHEASQC EPVGRVADII QIPAFLCRQT
     DLLVAAAKTG KIINIKKGQF CAPSVMANSA EKVRLAGNPN VMVCERGTMF GYNDLIVDPR
     NLEWMREANC PVVADITHSL QQPAGKKLDG GGVASGGLRE LIPCIARTSV AVGVDGIFME
     VHDDPLNAPV DGPTQWPLRH LEELLEELIA ISRVSKGKKP FNIDLTPFRE