ID   AR1AB_XENLA             Reviewed;         370 AA.
AC   A0A1L8EXB5;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 1A-B {ECO:0000305};
GN   Name=arpc1a-b; ORFNames=XELAEV_18045070mg {ECO:0000312|EMBL:OCT63973.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J;
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA   Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA   Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA   Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA   Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA   Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA   Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA   Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA   Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA   Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA   Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
CC   -!- FUNCTION: Probably functions as component of the Arp2/3 complex which
CC       is involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks (By similarity). In addition to its role in the
CC       cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin
CC       polymerization in the nucleus, thereby regulating gene transcription
CC       and repair of damaged DNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q8AVT9, ECO:0000250|UniProtKB:Q92747}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex.
CC       {ECO:0000250|UniProtKB:Q8AVT9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q92747}. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}.
CC   -!- SIMILARITY: Belongs to the WD repeat ARPC1 family. {ECO:0000305}.
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DR   EMBL; CM004482; OCT63973.1; -; Genomic_DNA.
DR   RefSeq; XP_018091747.1; XM_018236258.1.
DR   RefSeq; XP_018091748.1; XM_018236259.1.
DR   AlphaFoldDB; A0A1L8EXB5; -.
DR   SMR; A0A1L8EXB5; -.
DR   STRING; 8355.A0A1L8EXB5; -.
DR   GeneID; 108701505; -.
DR   KEGG; xla:108701505; -.
DR   CTD; 108701505; -.
DR   OMA; YVWEPSP; -.
DR   OrthoDB; 848569at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 108701505; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR030140; ARC1A.
DR   InterPro; IPR017383; ARPC1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10709; PTHR10709; 1.
DR   PANTHER; PTHR10709:SF11; PTHR10709:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..370
FT                   /note="Actin-related protein 2/3 complex subunit 1A-B"
FT                   /id="PRO_0000445568"
FT   REPEAT          6..45
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          140..179
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          202..241
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          244..284
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          322..365
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   370 AA;  41622 MW;  1A3C508A8F956114 CRC64;
     MSLHQFLLEP ITCHAWNKDL TQIAISPNNH EVHIYKNSGN QWVKCHELKE HNGHITGIDW
     APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI
     SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKTRVFS AYIKEVDEKP
     ASTPWGSKMP FGQMMAEFGG VSSGGWVHSV SFSASGNKLA WVSHDSTVSV ADASKNMSVS
     QLKTEFLPLL SVIFVSENSL IAAGHDCCPM LFTYDEQGSL TFVSKLDIPK QSTQRNISAM
     ERFRNMDKRA TTEDRNTTLE TLHQNSITQV SIYDGDKTDC RKFCTTGIDG AMTIWDFKTL
     ESYIQGLRIM