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AR1_XENLA
ID   AR1_XENLA               Reviewed;         228 AA.
AC   Q91827;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Apoptosis regulator R1;
DE   AltName: Full=XR1;
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head;
RX   PubMed=7607538; DOI=10.1016/0378-1119(95)00159-4;
RA   Cruz-Reyes J., Tata J.R.;
RT   "Cloning, characterization and expression of two Xenopus bcl-2-like cell-
RT   survival genes.";
RL   Gene 158:171-179(1995).
CC   -!- FUNCTION: Could be the homolog of mammalian Bcl-W.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Developmental regulation only occurs in the brain
CC       of mid-metamorphosic to post-metamorphosic tadpoles and adults, where
CC       an increase of several fold has been observed.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR   EMBL; X82462; CAA57845.1; -; mRNA.
DR   RefSeq; NP_001081573.2; NM_001088104.1.
DR   AlphaFoldDB; Q91827; -.
DR   SMR; Q91827; -.
DR   GeneID; 397930; -.
DR   KEGG; xla:397930; -.
DR   CTD; 397930; -.
DR   Xenbase; XB-GENE-6252167; bcl2l2.S.
DR   OrthoDB; 1218929at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 397930; Expressed in brain and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd06845; Bcl-2_like; 1.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR013280; Apop_reg_BclW.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   PANTHER; PTHR11256; PTHR11256; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   Pfam; PF02180; BH4; 1.
DR   PRINTS; PR01865; APOPREGBCLW.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SMART; SM00265; BH4; 1.
DR   SUPFAM; SSF56854; SSF56854; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..228
FT                   /note="Apoptosis regulator R1"
FT                   /id="PRO_0000143098"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           120..139
FT                   /note="BH1"
FT   MOTIF           171..186
FT                   /note="BH2"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   228 AA;  25068 MW;  C499D449A585F8A9 CRC64;
     LNPKKKENNG VKNGDREKQH ETGNTIFRGS PDKYLTEQGW MAQSDLGSRA LVEDLVRYKL
     CQRSLVPEPS GAASCALHSA MRAAGDEFEE RFRQAFSEIS TQIHVTPGTA YARFAEVAGS
     LFQGGVNWGR IVAFFVFGAA LCAESVNKEM SPLLPRIQDW MVTYLETNLR DWIQSNGGWN
     GFLTLYGDGA IEEARRQREG NWASLKTVLT GAVALGALMT VGALFASK
 
 
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