AR1_XENLA
ID AR1_XENLA Reviewed; 228 AA.
AC Q91827;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Apoptosis regulator R1;
DE AltName: Full=XR1;
DE Flags: Fragment;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Head;
RX PubMed=7607538; DOI=10.1016/0378-1119(95)00159-4;
RA Cruz-Reyes J., Tata J.R.;
RT "Cloning, characterization and expression of two Xenopus bcl-2-like cell-
RT survival genes.";
RL Gene 158:171-179(1995).
CC -!- FUNCTION: Could be the homolog of mammalian Bcl-W.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Developmental regulation only occurs in the brain
CC of mid-metamorphosic to post-metamorphosic tadpoles and adults, where
CC an increase of several fold has been observed.
CC -!- SIMILARITY: Belongs to the Bcl-2 family. {ECO:0000305}.
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DR EMBL; X82462; CAA57845.1; -; mRNA.
DR RefSeq; NP_001081573.2; NM_001088104.1.
DR AlphaFoldDB; Q91827; -.
DR SMR; Q91827; -.
DR GeneID; 397930; -.
DR KEGG; xla:397930; -.
DR CTD; 397930; -.
DR Xenbase; XB-GENE-6252167; bcl2l2.S.
DR OrthoDB; 1218929at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 397930; Expressed in brain and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; -; 1.
DR InterPro; IPR013280; Apop_reg_BclW.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR InterPro; IPR003093; Bcl2_BH4.
DR PANTHER; PTHR11256; PTHR11256; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR Pfam; PF02180; BH4; 1.
DR PRINTS; PR01865; APOPREGBCLW.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SMART; SM00265; BH4; 1.
DR SUPFAM; SSF56854; SSF56854; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
DR PROSITE; PS01080; BH1; 1.
DR PROSITE; PS01258; BH2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN <1..228
FT /note="Apoptosis regulator R1"
FT /id="PRO_0000143098"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 120..139
FT /note="BH1"
FT MOTIF 171..186
FT /note="BH2"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
SQ SEQUENCE 228 AA; 25068 MW; C499D449A585F8A9 CRC64;
LNPKKKENNG VKNGDREKQH ETGNTIFRGS PDKYLTEQGW MAQSDLGSRA LVEDLVRYKL
CQRSLVPEPS GAASCALHSA MRAAGDEFEE RFRQAFSEIS TQIHVTPGTA YARFAEVAGS
LFQGGVNWGR IVAFFVFGAA LCAESVNKEM SPLLPRIQDW MVTYLETNLR DWIQSNGGWN
GFLTLYGDGA IEEARRQREG NWASLKTVLT GAVALGALMT VGALFASK