ID   AR2BP_DANRE             Reviewed;         168 AA.
AC   Q7SYL1; Q6NYS0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=ADP-ribosylation factor-like protein 2-binding protein;
DE            Short=ARF-like 2-binding protein;
GN   Name=arl2bp;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as an effector of the ADP-ribosylation factor-
CC       like protein 2, ARL2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       intermembrane space {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250}. Note=Detected in the
CC       midbody matrix. Not detected in the Golgi, nucleus and on the mitotic
CC       spindle. Centrosome-associated throughout the cell cycle. Not detected
CC       to interphase microtubules. The complex formed with ARL2BP, ARL2 and
CC       SLC25A4 is expressed in mitochondria (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARL2BP family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH54678.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH66483.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC054678; AAH54678.1; ALT_INIT; mRNA.
DR   EMBL; BC066483; AAH66483.2; ALT_INIT; mRNA.
DR   RefSeq; XP_009291821.1; XM_009293546.2.
DR   PDB; 2K0S; NMR; -; A=19-139.
DR   PDBsum; 2K0S; -.
DR   AlphaFoldDB; Q7SYL1; -.
DR   SMR; Q7SYL1; -.
DR   STRING; 7955.ENSDARP00000110496; -.
DR   PaxDb; Q7SYL1; -.
DR   DNASU; 393976; -.
DR   ZFIN; ZDB-GENE-040426-1604; arl2bp.
DR   eggNOG; ENOG502RYJD; Eukaryota.
DR   InParanoid; Q7SYL1; -.
DR   OrthoDB; 1403493at2759; -.
DR   PhylomeDB; Q7SYL1; -.
DR   Reactome; R-DRE-83936; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.
DR   EvolutionaryTrace; Q7SYL1; -.
DR   PRO; PR:Q7SYL1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0051457; P:maintenance of protein location in nucleus; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   Gene3D; 1.20.1520.10; -; 1.
DR   InterPro; IPR038849; ARL2BP.
DR   InterPro; IPR023379; BART_dom.
DR   InterPro; IPR042541; BART_sf.
DR   PANTHER; PTHR15487; PTHR15487; 1.
DR   Pfam; PF11527; ARL2_Bind_BART; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW   Mitochondrion; Nucleus; Reference proteome.
FT   CHAIN           1..168
FT                   /note="ADP-ribosylation factor-like protein 2-binding
FT                   protein"
FT                   /id="PRO_0000287119"
FT   HELIX           22..34
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   HELIX           38..53
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   HELIX           65..85
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   STRAND          90..92
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   HELIX           96..100
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   HELIX           104..106
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   HELIX           109..116
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   HELIX           117..119
FT                   /evidence="ECO:0007829|PDB:2K0S"
FT   HELIX           121..136
FT                   /evidence="ECO:0007829|PDB:2K0S"
SQ   SEQUENCE   168 AA;  19296 MW;  90ACE22CF1130535 CRC64;
     MVDMQSLDEE DFSVSKSSDA DAEFDIVIGN IEDIIMEDEF QHLQQSFMEK YYLEFDDSEE
     NKLSYTPIFN EYIEILEKHL EQQLVERIPG FNMDAFTHSL KQHKDEVSGD ILDMLLTFTD
     FMAFKEMFTD YRAEKEGRGL DLSTGLVVKS LNSSSASPLT PSMASQSI