ID   AR2BP_PONAB             Reviewed;         163 AA.
AC   Q5R9K8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=ADP-ribosylation factor-like protein 2-binding protein;
DE            Short=ARF-like 2-binding protein;
GN   Name=ARL2BP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Together with ARL2, plays a role in the nuclear
CC       translocation, retention and transcriptional activity of STAT3. May
CC       play a role as an effector of ARL2 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GTP bound ARL2 and ARL3; the complex ARL2-
CC       ARL2BP as well as ARL2BP alone, binds to SLC25A4/ANT1. Interaction with
CC       ARL2 may be required for cilia basal body localization (By similarity).
CC       Interacts with STAT3; interaction is enhanced with ARL2. Found in a
CC       complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2,
CC       ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       intermembrane space {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250}. Note=Detected in the
CC       midbody matrix. Not detected in the Golgi, nucleus and on the mitotic
CC       spindle. Centrosome-associated throughout the cell cycle. Not detected
CC       to interphase microtubules. In retina photoreceptor cells, localized in
CC       the distal connecting cilia, basal body, ciliary-associated centriole,
CC       and ciliary rootlet. Interaction with ARL2 may be required for cilia
CC       basal body localization (By similarity). The complex formed with
CC       ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARL2BP family. {ECO:0000305}.
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DR   EMBL; CR859379; CAH91552.1; -; mRNA.
DR   RefSeq; NP_001125911.1; NM_001132439.2.
DR   AlphaFoldDB; Q5R9K8; -.
DR   BMRB; Q5R9K8; -.
DR   SMR; Q5R9K8; -.
DR   STRING; 9601.ENSPPYP00000008341; -.
DR   Ensembl; ENSPPYT00000008682; ENSPPYP00000008341; ENSPPYG00000007384.
DR   GeneID; 100172844; -.
DR   KEGG; pon:100172844; -.
DR   CTD; 23568; -.
DR   eggNOG; ENOG502RYJD; Eukaryota.
DR   GeneTree; ENSGT00390000015052; -.
DR   HOGENOM; CLU_116781_0_0_1; -.
DR   InParanoid; Q5R9K8; -.
DR   OMA; LIQRNFM; -.
DR   OrthoDB; 1403493at2759; -.
DR   TreeFam; TF315143; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0051457; P:maintenance of protein location in nucleus; ISS:UniProtKB.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.
DR   Gene3D; 1.20.1520.10; -; 1.
DR   InterPro; IPR038849; ARL2BP.
DR   InterPro; IPR023379; BART_dom.
DR   InterPro; IPR042541; BART_sf.
DR   PANTHER; PTHR15487; PTHR15487; 1.
DR   Pfam; PF11527; ARL2_Bind_BART; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Mitochondrion; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..163
FT                   /note="ADP-ribosylation factor-like protein 2-binding
FT                   protein"
FT                   /id="PRO_0000287116"
SQ   SEQUENCE   163 AA;  18852 MW;  5A2964E577AE824B CRC64;
     MDALEEESFA LSFSSTSDAE FDAVVGYLED IIMDDEFQLL QRNFMDKYYL EFEDTEENKL
     IYTPIFNEYI SLVEKYIEEQ LLQRIPGFNM AAFTTTLQHH KDEVAGDIFD MLLTFTDFLA
     FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK SSSLPASQNN LRH