AR2BP_RAT
ID AR2BP_RAT Reviewed; 163 AA.
AC Q4V8C5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=ADP-ribosylation factor-like protein 2-binding protein;
DE Short=ARF-like 2-binding protein;
DE AltName: Full=Binder of ARF2 protein 1;
GN Name=Arl2bp; Synonyms=Bart, Bart1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11809823; DOI=10.1091/mbc.01-05-0245;
RA Sharer J.D., Shern J.F., Van Valkenburgh H., Wallace D.C., Kahn R.A.;
RT "ARL2 and BART enter mitochondria and bind the adenine nucleotide
RT transporter.";
RL Mol. Biol. Cell 13:71-83(2002).
CC -!- FUNCTION: Together with ARL2, plays a role in the nuclear
CC translocation, retention and transcriptional activity of STAT3. May
CC play a role as an effector of ARL2 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with GTP bound ARL2 and ARL3; the complex ARL2-
CC ARL2BP as well as ARL2BP alone, binds to SLC25A4/ANT1. Interaction with
CC ARL2 may be required for cilia basal body localization (By similarity).
CC Interacts with STAT3; interaction is enhanced with ARL2. Found in a
CC complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2,
CC ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC intermembrane space {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000250}. Note=Detected in the
CC midbody matrix. Not detected in the Golgi, nucleus and on the mitotic
CC spindle. Centrosome-associated throughout the cell cycle. Not detected
CC to interphase microtubules. In retina photoreceptor cells, localized in
CC the distal connecting cilia, basal body, ciliary-associated centriole,
CC and ciliary rootlet. Interaction with ARL2 may be required for cilia
CC basal body localization (By similarity). The complex formed with
CC ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity).
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4V8C5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4V8C5-2; Sequence=VSP_025321;
CC -!- TISSUE SPECIFICITY: Ubiquitous with higher expression in brain,
CC especially in hippocampus and cortex. Also expressed in lung,
CC cerebellum, liver, kidney, spleen and heart (at protein level).
CC {ECO:0000269|PubMed:11809823}.
CC -!- SIMILARITY: Belongs to the ARL2BP family. {ECO:0000305}.
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DR EMBL; BC097448; AAH97448.1; -; mRNA.
DR EMBL; CV113398; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001020077.1; NM_001024906.1. [Q4V8C5-2]
DR RefSeq; XP_006255182.1; XM_006255120.3. [Q4V8C5-1]
DR RefSeq; XP_017456828.1; XM_017601339.1. [Q4V8C5-2]
DR AlphaFoldDB; Q4V8C5; -.
DR SMR; Q4V8C5; -.
DR STRING; 10116.ENSRNOP00000023455; -.
DR PaxDb; Q4V8C5; -.
DR Ensembl; ENSRNOT00000023455; ENSRNOP00000023455; ENSRNOG00000016991. [Q4V8C5-1]
DR GeneID; 498910; -.
DR KEGG; rno:498910; -.
DR UCSC; RGD:1561471; rat. [Q4V8C5-1]
DR CTD; 23568; -.
DR RGD; 1561471; Arl2bp.
DR eggNOG; ENOG502RYJD; Eukaryota.
DR GeneTree; ENSGT00390000015052; -.
DR HOGENOM; CLU_116781_2_0_1; -.
DR InParanoid; Q4V8C5; -.
DR OrthoDB; 1403493at2759; -.
DR PhylomeDB; Q4V8C5; -.
DR Reactome; R-RNO-83936; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.
DR PRO; PR:Q4V8C5; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000016991; Expressed in Ammon's horn and 20 other tissues.
DR ExpressionAtlas; Q4V8C5; baseline and differential.
DR Genevisible; Q4V8C5; RN.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0030496; C:midbody; ISO:RGD.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0051457; P:maintenance of protein location in nucleus; ISS:UniProtKB.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.
DR Gene3D; 1.20.1520.10; -; 1.
DR InterPro; IPR038849; ARL2BP.
DR InterPro; IPR023379; BART_dom.
DR InterPro; IPR042541; BART_sf.
DR PANTHER; PTHR15487; PTHR15487; 1.
DR Pfam; PF11527; ARL2_Bind_BART; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW Mitochondrion; Nucleus; Reference proteome.
FT CHAIN 1..163
FT /note="ADP-ribosylation factor-like protein 2-binding
FT protein"
FT /id="PRO_0000287117"
FT VAR_SEQ 1..32
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025321"
SQ SEQUENCE 163 AA; 18683 MW; A1998B08C0383825 CRC64;
MDALEEESFA LSFSSASDAE FDAVVGCLED IIMDAEFQLL QRSFMDKYYQ EFEDTEENKL
TYTPIFNEYI SLVEKYIEEQ LLERIPGFNM AAFTTTLQHH KDEVAGDIFD MLLTFTDFLA
FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK SSSTPASQNN LRH
