ID   AR2BP_XENLA             Reviewed;         156 AA.
AC   Q6DDX7; Q6GLJ7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=ADP-ribosylation factor-like protein 2-binding protein;
DE            Short=ARF-like 2-binding protein;
GN   Name=arl2bp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, Embryo, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as an effector of the ADP-ribosylation factor-
CC       like protein 2, ARL2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       intermembrane space {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250}. Note=Detected in the
CC       midbody matrix. Not detected in the Golgi, nucleus and on the mitotic
CC       spindle. Centrosome-associated throughout the cell cycle. Not detected
CC       to interphase microtubules. The complex formed with ARL2BP, ARL2 and
CC       SLC25A4 is expressed in mitochondria (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6DDX7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6DDX7-2; Sequence=VSP_025322, VSP_025323;
CC   -!- SIMILARITY: Belongs to the ARL2BP family. {ECO:0000305}.
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DR   EMBL; BC074487; AAH74487.1; -; mRNA.
DR   EMBL; BC077374; AAH77374.1; -; mRNA.
DR   EMBL; BC108523; AAI08524.1; -; mRNA.
DR   RefSeq; NP_001086325.1; NM_001092856.1. [Q6DDX7-1]
DR   AlphaFoldDB; Q6DDX7; -.
DR   SMR; Q6DDX7; -.
DR   DNASU; 444754; -.
DR   GeneID; 444754; -.
DR   KEGG; xla:444754; -.
DR   CTD; 444754; -.
DR   Xenbase; XB-GENE-6254371; arl2bp.L.
DR   OrthoDB; 1403493at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 444754; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1520.10; -; 1.
DR   InterPro; IPR038849; ARL2BP.
DR   InterPro; IPR023379; BART_dom.
DR   InterPro; IPR042541; BART_sf.
DR   PANTHER; PTHR15487; PTHR15487; 1.
DR   Pfam; PF11527; ARL2_Bind_BART; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW   Mitochondrion; Nucleus; Reference proteome.
FT   CHAIN           1..156
FT                   /note="ADP-ribosylation factor-like protein 2-binding
FT                   protein"
FT                   /id="PRO_0000287120"
FT   VAR_SEQ         70..101
FT                   /note="IGLVEKYIEEQLLQRIPAFDMSAFTSSLQCHR -> VSCKLNLSVLLPYLLC
FT                   NLSTLRFHPVSVTKNT (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_025322"
FT   VAR_SEQ         102..156
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_025323"
SQ   SEQUENCE   156 AA;  17981 MW;  DC8543FE99E26C75 CRC64;
     MEDLEEENFS LSVSSPKDAE FDNVVGHLED IIMDDEFQLL QHGFMDKHYH EFEDTEENKL
     TYTTIFNEYI GLVEKYIEEQ LLQRIPAFDM SAFTSSLQCH REEIAGDIFD ILLTFTDFLA
     FKEMFLDYKA EKEGRTVDLG CGLVVTSLMS SSISSS