ID   AR6P1_PONAB             Reviewed;         203 AA.
AC   Q5R454;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=ADP-ribosylation factor-like protein 6-interacting protein 1;
DE            Short=ARL-6-interacting protein 1;
DE            Short=Aip-1;
DE   AltName: Full=Protein TBX2;
GN   Name=ARL6IP1; Synonyms=ARL6IP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates SLC1A1/EAAC1-mediated glutamate
CC       transport by increasing its affinity for glutamate in a PKC activity-
CC       dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1
CC       probably by reducing its interaction with ARL6IP5, a negative regulator
CC       of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the
CC       formation and stabilization of endoplasmic reticulum tubules.
CC       Negatively regulates apoptosis, possibly by modulating the activity of
CC       caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and
CC       downstream markers of apoptosis but not CASP9 itself. May be involved
CC       in protein transport, membrane trafficking, or cell signaling during
CC       hematopoietic maturation. {ECO:0000250|UniProtKB:Q15041,
CC       ECO:0000250|UniProtKB:Q9JKW0}.
CC   -!- SUBUNIT: Homooligomer. Heterodimer with ARL6IP5. Interacts with ATL1,
CC       TMEM33 and ARL6. {ECO:0000250|UniProtKB:Q15041,
CC       ECO:0000250|UniProtKB:Q9JKW0}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system
CC       {ECO:0000250|UniProtKB:Q15041}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q15041}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9JKW0}.
CC       Note=Predominantly localized to intracytoplasmic membranes.
CC       Preferentially localizes at the ER tubules and the edge of the ER
CC       sheets, both of which are characterized by a high membrane curvature.
CC       {ECO:0000250|UniProtKB:Q15041}.
CC   -!- DOMAIN: The transmembrane domains are required for its ability to shape
CC       the endoplasmic reticulum membrane into tubules.
CC       {ECO:0000250|UniProtKB:Q15041}.
CC   -!- SIMILARITY: Belongs to the ARL6ip family. {ECO:0000305}.
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DR   EMBL; CR861404; CAH93462.1; -; mRNA.
DR   RefSeq; NP_001127029.1; NM_001133557.2.
DR   AlphaFoldDB; Q5R454; -.
DR   STRING; 9601.ENSPPYP00000008071; -.
DR   Ensembl; ENSPPYT00000008406; ENSPPYP00000008071; ENSPPYG00000007140.
DR   GeneID; 100174054; -.
DR   KEGG; pon:100174054; -.
DR   CTD; 23204; -.
DR   eggNOG; ENOG502QTTI; Eukaryota.
DR   GeneTree; ENSGT00940000154937; -.
DR   HOGENOM; CLU_100749_0_0_1; -.
DR   InParanoid; Q5R454; -.
DR   OMA; VWYEYLF; -.
DR   OrthoDB; 1268983at2759; -.
DR   TreeFam; TF105477; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0071787; P:endoplasmic reticulum tubular network formation; ISS:UniProtKB.
DR   GO; GO:1990809; P:endoplasmic reticulum tubular network membrane organization; ISS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0002038; P:positive regulation of L-glutamate import across plasma membrane; ISS:UniProtKB.
DR   InterPro; IPR033301; ARL6IP.
DR   PANTHER; PTHR20952:SF3; PTHR20952:SF3; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..203
FT                   /note="ADP-ribosylation factor-like protein 6-interacting
FT                   protein 1"
FT                   /id="PRO_0000064657"
FT   TOPO_DOM        1..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..65
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..203
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   203 AA;  23323 MW;  7A979440DBAD5065 CRC64;
     MAEGDNRSSN LLAAETASLE EQLQGWGEVM LMADKVLRWE RAWFPPAIMG VVSLVFLIIY
     YLDPSVLSGV SCFVMFLCLA DYLVPILAPR IFGSNKWTTE QQQRFHEICS NLVKTRRRAV
     GWWKRLFTLK EEKPKMYFMT MIVSLAAVAW VGQQVHNLLL TYLIVTSLLL LPGLNQHGII
     SKYIGMAKRE INKLLKQKEK KNE