AR6P4_DANRE
ID AR6P4_DANRE Reviewed; 221 AA.
AC Q502P0;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=ADP-ribosylation factor-like protein 6-interacting protein 4;
DE Short=ARL-6-interacting protein 4;
DE Short=Aip-4;
GN Name=arl6ip4; ORFNames=si:ch211-275j6.4, zgc:111967;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larval eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in modulating alternative pre-mRNA splicing.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Nucleus speckle
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ARL6IP4 family. {ECO:0000305}.
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DR EMBL; CR847941; CAN87844.1; -; Genomic_DNA.
DR EMBL; BC095624; AAH95624.1; -; mRNA.
DR RefSeq; NP_001018594.1; NM_001020758.1.
DR AlphaFoldDB; Q502P0; -.
DR STRING; 7955.ENSDARP00000124884; -.
DR PaxDb; Q502P0; -.
DR PRIDE; Q502P0; -.
DR Ensembl; ENSDART00000169013; ENSDARP00000137044; ENSDARG00000105036.
DR Ensembl; ENSDART00000182043; ENSDARP00000147318; ENSDARG00000110324.
DR GeneID; 553796; -.
DR KEGG; dre:553796; -.
DR CTD; 51329; -.
DR ZFIN; ZDB-GENE-050522-405; arl6ip4.
DR eggNOG; ENOG502RYBZ; Eukaryota.
DR GeneTree; ENSGT00390000009670; -.
DR HOGENOM; CLU_055563_1_0_1; -.
DR InParanoid; Q502P0; -.
DR OMA; WHQSAWE; -.
DR OrthoDB; 1552427at2759; -.
DR TreeFam; TF350468; -.
DR PRO; PR:Q502P0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000105036; Expressed in gastrula and 29 other tissues.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR019532; Nucl_RNA-splicing_assoc_SR-25.
DR Pfam; PF10500; SR-25; 1.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT CHAIN 1..221
FT /note="ADP-ribosylation factor-like protein 6-interacting
FT protein 4"
FT /id="PRO_0000312274"
FT REGION 1..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..101
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 221 AA; 25369 MW; DA8DCF0347E956FC CRC64;
MGGSDSDSRS RSRNREENKS RSLSSSSARR PSPNHEKKHE HSSEKKKMKR RRSSSSSSSS
SSPSPSREKK AKKKKKRREA KKLKREKKKE KKEKKRQKKL ALKAERAAAL TASVPAPVPE
EKPQTYLKTW QSEETKEHGP AMTDEQKAKL STRRPLTKEE YEARQSVIRR VLDPETGRTR
LIRGDGEILE EIVSKERHKD INKQSTRGDG DAFQKRLGIS R
