ID   AR6P4_RAT               Reviewed;         231 AA.
AC   Q4V8I5; Q499T6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=ADP-ribosylation factor-like protein 6-interacting protein 4;
DE            Short=ARL-6-interacting protein 4;
DE            Short=Aip-4;
DE   AltName: Full=Splicing factor SRrp37;
GN   Name=Arl6ip4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Involved in modulating alternative pre-mRNA splicing with
CC       either 5' distal site activation or preferential use of 3' proximal
CC       site. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ARL6. Interacts with ZCCHC17. Interacts with
CC       SRSF2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Nucleus speckle
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARL6IP4 family. {ECO:0000305}.
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DR   EMBL; BC097374; AAH97374.1; -; mRNA.
DR   RefSeq; NP_001020801.1; NM_001025630.1.
DR   AlphaFoldDB; Q4V8I5; -.
DR   STRING; 10116.ENSRNOP00000001432; -.
DR   iPTMnet; Q4V8I5; -.
DR   PhosphoSitePlus; Q4V8I5; -.
DR   PaxDb; Q4V8I5; -.
DR   PRIDE; Q4V8I5; -.
DR   Ensembl; ENSRNOT00000001432; ENSRNOP00000001432; ENSRNOG00000001080.
DR   GeneID; 288656; -.
DR   KEGG; rno:288656; -.
DR   UCSC; RGD:1307657; rat.
DR   CTD; 51329; -.
DR   RGD; 1307657; Arl6ip4.
DR   eggNOG; ENOG502RYBZ; Eukaryota.
DR   GeneTree; ENSGT00390000009670; -.
DR   HOGENOM; CLU_055563_0_0_1; -.
DR   InParanoid; Q4V8I5; -.
DR   OMA; FQMRTGM; -.
DR   OrthoDB; 1479900at2759; -.
DR   PhylomeDB; Q4V8I5; -.
DR   TreeFam; TF350468; -.
DR   PRO; PR:Q4V8I5; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001080; Expressed in duodenum and 20 other tissues.
DR   Genevisible; Q4V8I5; RN.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR019532; Nucl_RNA-splicing_assoc_SR-25.
DR   Pfam; PF10500; SR-25; 1.
PE   1: Evidence at protein level;
KW   Isopeptide bond; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..231
FT                   /note="ADP-ribosylation factor-like protein 6-interacting
FT                   protein 4"
FT                   /id="PRO_0000312272"
FT   REGION          1..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..120
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         142
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         176
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q66PJ3"
FT   CROSSLNK        193
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q66PJ3"
SQ   SEQUENCE   231 AA;  25769 MW;  C198983F0EEC9357 CRC64;
     MAHVSSRKRS RSRSRSRGRR GSEKRSKRSS KDSSRNCSTS KSQGHKASST SGVEERSKHK
     AQRTSRSSSS SSSSSSSSSS SSTSSSSSSD GRKKRGKHKD KKKRKKKKKR KKKMKRKGKE
     KAVVVHQAEA LPGPSLDQWH RSAGEDNDGP VLTDEQKSRI QAMKPMTKEE WDARQSVIRK
     VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDG LAFQMRAGLL P