AR6P6_HUMAN
ID AR6P6_HUMAN Reviewed; 226 AA.
AC Q8N6S5; B2RDS6; Q7Z4G7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=ADP-ribosylation factor-like protein 6-interacting protein 6;
DE Short=ARL-6-interacting protein 6;
DE Short=Aip-6;
DE AltName: Full=Phosphonoformate immuno-associated protein 1;
GN Name=ARL6IP6; Synonyms=PFAAP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Liu Y., Cheng J., Lu Y.;
RT "Screening and cloning of a new immuno-associated gene regulated by
RT phosphonoformate.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Esophagus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-36 AND SER-65, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-65, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65 AND SER-80, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8N6S5; Q13520: AQP6; NbExp=3; IntAct=EBI-2808844, EBI-13059134;
CC Q8N6S5; A0PK11: CLRN2; NbExp=3; IntAct=EBI-2808844, EBI-12813623;
CC Q8N6S5; Q8TAZ6: CMTM2; NbExp=3; IntAct=EBI-2808844, EBI-2339374;
CC Q8N6S5; Q15125: EBP; NbExp=3; IntAct=EBI-2808844, EBI-3915253;
CC Q8N6S5; P48165: GJA8; NbExp=3; IntAct=EBI-2808844, EBI-17458373;
CC Q8N6S5; Q9BZJ8: GPR61; NbExp=3; IntAct=EBI-2808844, EBI-12808020;
CC Q8N6S5; O14880: MGST3; NbExp=3; IntAct=EBI-2808844, EBI-724754;
CC Q8N6S5; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-2808844, EBI-8636004;
CC Q8N6S5; Q14973: SLC10A1; NbExp=3; IntAct=EBI-2808844, EBI-3923031;
CC Q8N6S5; Q0VAB0: TBXA2R; NbExp=3; IntAct=EBI-2808844, EBI-18271435;
CC Q8N6S5; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-2808844, EBI-6268651;
CC Q8N6S5; Q6UW68: TMEM205; NbExp=3; IntAct=EBI-2808844, EBI-6269551;
CC Q8N6S5; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-2808844, EBI-11742770;
CC Q8N6S5; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-2808844, EBI-2548832;
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q8BH07}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ARL6IP6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF530059; AAQ09943.1; -; mRNA.
DR EMBL; AK315657; BAG38023.1; -; mRNA.
DR EMBL; AC079344; AAX93217.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11477.1; -; Genomic_DNA.
DR EMBL; BC028741; AAH28741.1; -; mRNA.
DR EMBL; BC070140; AAH70140.1; -; mRNA.
DR CCDS; CCDS2197.1; -.
DR RefSeq; NP_689735.1; NM_152522.5.
DR AlphaFoldDB; Q8N6S5; -.
DR BioGRID; 127351; 64.
DR IntAct; Q8N6S5; 33.
DR MINT; Q8N6S5; -.
DR STRING; 9606.ENSP00000315357; -.
DR iPTMnet; Q8N6S5; -.
DR PhosphoSitePlus; Q8N6S5; -.
DR SwissPalm; Q8N6S5; -.
DR BioMuta; ARL6IP6; -.
DR DMDM; 74729171; -.
DR EPD; Q8N6S5; -.
DR jPOST; Q8N6S5; -.
DR MassIVE; Q8N6S5; -.
DR MaxQB; Q8N6S5; -.
DR PaxDb; Q8N6S5; -.
DR PeptideAtlas; Q8N6S5; -.
DR PRIDE; Q8N6S5; -.
DR ProteomicsDB; 72225; -.
DR Antibodypedia; 3110; 102 antibodies from 23 providers.
DR DNASU; 151188; -.
DR Ensembl; ENST00000326446.10; ENSP00000315357.5; ENSG00000177917.12.
DR GeneID; 151188; -.
DR KEGG; hsa:151188; -.
DR MANE-Select; ENST00000326446.10; ENSP00000315357.5; NM_152522.7; NP_689735.1.
DR UCSC; uc002tyn.4; human.
DR CTD; 151188; -.
DR DisGeNET; 151188; -.
DR GeneCards; ARL6IP6; -.
DR HGNC; HGNC:24048; ARL6IP6.
DR HPA; ENSG00000177917; Low tissue specificity.
DR MalaCards; ARL6IP6; -.
DR MIM; 616495; gene.
DR neXtProt; NX_Q8N6S5; -.
DR OpenTargets; ENSG00000177917; -.
DR Orphanet; 1556; Cutis marmorata telangiectatica congenita.
DR PharmGKB; PA134866669; -.
DR VEuPathDB; HostDB:ENSG00000177917; -.
DR eggNOG; ENOG502S1PC; Eukaryota.
DR GeneTree; ENSGT00390000009987; -.
DR HOGENOM; CLU_1229535_0_0_1; -.
DR InParanoid; Q8N6S5; -.
DR OMA; SFAESGW; -.
DR OrthoDB; 1552769at2759; -.
DR PhylomeDB; Q8N6S5; -.
DR TreeFam; TF324669; -.
DR PathwayCommons; Q8N6S5; -.
DR SignaLink; Q8N6S5; -.
DR BioGRID-ORCS; 151188; 16 hits in 1078 CRISPR screens.
DR ChiTaRS; ARL6IP6; human.
DR GenomeRNAi; 151188; -.
DR Pharos; Q8N6S5; Tdark.
DR PRO; PR:Q8N6S5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N6S5; protein.
DR Bgee; ENSG00000177917; Expressed in ventricular zone and 184 other tissues.
DR ExpressionAtlas; Q8N6S5; baseline and differential.
DR Genevisible; Q8N6S5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR InterPro; IPR029383; ARL6IP6.
DR PANTHER; PTHR28640; PTHR28640; 1.
DR Pfam; PF15062; ARL6IP6; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..226
FT /note="ADP-ribosylation factor-like protein 6-interacting
FT protein 6"
FT /id="PRO_0000307324"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
FT MOD_RES 80
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CONFLICT 21
FT /note="G -> A (in Ref. 1; AAQ09943)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 24676 MW; EB236F4490BE1FFF CRC64;
MSFAESGWRS ALRRRGPGTP GPVARPSYSS FTQGDSWGEG EVDEEEGCDQ VARDLRAEFS
AGAWSEPRKR SVLPPDGNGS PVLPDKRNGI FPAAAGSRAQ PRRWPVQVLS ILCSLLFAIL
LAFLLAIAYL IVKELHAENL KNEDDVDTGL LGFWTLLIIS LTAGFSCCSF SWTVTYFDSF
EPGMFPPTPL SPARFKKLTG HSFHMGYSMA ILNGIVAALT VAWCLM
