AR6P6_MOUSE
ID AR6P6_MOUSE Reviewed; 226 AA.
AC Q8BH07; Q8BSK7; Q8VCL3; Q9CY07; Q9D4R5; Q9WUH0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=ADP-ribosylation factor-like protein 6-interacting protein 6;
DE Short=ARL-6-interacting protein 6;
DE Short=Aip-6;
GN Name=Arl6ip6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Embryonic stem cell, Fetal eye, Liver, Testis, Urinary bladder, and
RC Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-125.
RX PubMed=10508919; DOI=10.1016/s0014-5793(99)01188-6;
RA Ingley E., Williams J.H., Walker C.E., Tsai S., Colley S., Sayer M.S.,
RA Tilbrook P.A., Sarna M., Beaumont J.G., Klinken S.P.;
RT "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-
RT conducting channel SEC61beta subunit.";
RL FEBS Lett. 459:69-74(1999).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=31142202; DOI=10.1080/19491034.2019.1618175;
RA Cheng L.C., Baboo S., Lindsay C., Brusman L., Martinez-Bartolome S.,
RA Tapia O., Zhang X., Yates J.R. III, Gerace L.;
RT "Identification of new transmembrane proteins concentrated at the nuclear
RT envelope using organellar proteomics of mesenchymal cells.";
RL Nucleus 10:126-143(2019).
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000269|PubMed:31142202}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ARL6IP6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD33051.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
CC Sequence=BAB27377.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK011070; BAB27377.1; ALT_FRAME; mRNA.
DR EMBL; AK016267; BAB30169.1; -; mRNA.
DR EMBL; AK032740; BAC28004.1; -; mRNA.
DR EMBL; AK035521; BAC29090.1; -; mRNA.
DR EMBL; AK052010; BAC34831.1; -; mRNA.
DR EMBL; AK082824; BAC38638.1; -; mRNA.
DR EMBL; AK159990; BAE35540.1; -; mRNA.
DR EMBL; AL844552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL845170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019550; AAH19550.1; -; mRNA.
DR EMBL; AF133913; AAD33051.1; ALT_SEQ; mRNA.
DR CCDS; CCDS16039.1; -.
DR RefSeq; NP_075365.3; NM_022989.4.
DR AlphaFoldDB; Q8BH07; -.
DR STRING; 10090.ENSMUSP00000028336; -.
DR iPTMnet; Q8BH07; -.
DR PhosphoSitePlus; Q8BH07; -.
DR SwissPalm; Q8BH07; -.
DR EPD; Q8BH07; -.
DR jPOST; Q8BH07; -.
DR MaxQB; Q8BH07; -.
DR PaxDb; Q8BH07; -.
DR PRIDE; Q8BH07; -.
DR ProteomicsDB; 283252; -.
DR Antibodypedia; 3110; 102 antibodies from 23 providers.
DR DNASU; 65103; -.
DR Ensembl; ENSMUST00000028336; ENSMUSP00000028336; ENSMUSG00000026960.
DR GeneID; 65103; -.
DR KEGG; mmu:65103; -.
DR UCSC; uc008jro.2; mouse.
DR CTD; 151188; -.
DR MGI; MGI:1929507; Arl6ip6.
DR VEuPathDB; HostDB:ENSMUSG00000026960; -.
DR eggNOG; ENOG502S1PC; Eukaryota.
DR GeneTree; ENSGT00390000009987; -.
DR HOGENOM; CLU_1229535_0_0_1; -.
DR InParanoid; Q8BH07; -.
DR OMA; SFAESGW; -.
DR OrthoDB; 1552769at2759; -.
DR PhylomeDB; Q8BH07; -.
DR TreeFam; TF324669; -.
DR BioGRID-ORCS; 65103; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Arl6ip6; mouse.
DR PRO; PR:Q8BH07; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BH07; protein.
DR Bgee; ENSMUSG00000026960; Expressed in medial ganglionic eminence and 252 other tissues.
DR Genevisible; Q8BH07; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.
DR InterPro; IPR029383; ARL6IP6.
DR PANTHER; PTHR28640; PTHR28640; 1.
DR Pfam; PF15062; ARL6IP6; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..226
FT /note="ADP-ribosylation factor-like protein 6-interacting
FT protein 6"
FT /id="PRO_0000307325"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 80
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT CONFLICT 11
FT /note="G -> W (in Ref. 1; BAB27377)"
FT /evidence="ECO:0000305"
FT CONFLICT 15
FT /note="R -> A (in Ref. 1; BAB27377)"
FT /evidence="ECO:0000305"
FT CONFLICT 15
FT /note="R -> P (in Ref. 1; BAB30169)"
FT /evidence="ECO:0000305"
FT CONFLICT 45
FT /note="D -> N (in Ref. 4; AAD33051)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="G -> V (in Ref. 1; BAC28004)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="I -> V (in Ref. 3; AAH19550)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 24909 MW; 5BE5F8084261F43B CRC64;
MSFVESWRFA GARRRRQVTP GPATRPGYSD YTQGDSWGEG EGDEDEGCDQ VARDLRAEFS
ARASSETKRA PLLPRVGDGS PVLPDKRNGI FPATAAKRTQ ARRWPIQALS ILCSLLFAVL
LAFLLAIAYM IVKELHAENL KNEDDIHTGL LGFWSLLIIS LTAGLSCCSF SWTVTYFDSF
EPGMFPPTPL SPARFKKLTG HSFHMGYSMA ILNGIVAALT VAWCLM
