AR6P6_RAT
ID AR6P6_RAT Reviewed; 223 AA.
AC Q68FV2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=ADP-ribosylation factor-like protein 6-interacting protein 6;
DE Short=ARL-6-interacting protein 6;
DE Short=Aip-6;
GN Name=Arl6ip6;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q8BH07}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ARL6IP6 family. {ECO:0000305}.
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DR EMBL; BC079329; AAH79329.1; -; mRNA.
DR RefSeq; NP_001019481.1; NM_001024310.1.
DR AlphaFoldDB; Q68FV2; -.
DR STRING; 10116.ENSRNOP00000006774; -.
DR iPTMnet; Q68FV2; -.
DR PhosphoSitePlus; Q68FV2; -.
DR PaxDb; Q68FV2; -.
DR Ensembl; ENSRNOT00000006774; ENSRNOP00000006774; ENSRNOG00000005074.
DR GeneID; 499798; -.
DR KEGG; rno:499798; -.
DR UCSC; RGD:1564819; rat.
DR CTD; 151188; -.
DR RGD; 1564819; Arl6ip6.
DR eggNOG; ENOG502S1PC; Eukaryota.
DR GeneTree; ENSGT00390000009987; -.
DR HOGENOM; CLU_1229535_0_0_1; -.
DR InParanoid; Q68FV2; -.
DR OMA; SFAESGW; -.
DR OrthoDB; 1552769at2759; -.
DR PhylomeDB; Q68FV2; -.
DR TreeFam; TF324669; -.
DR PRO; PR:Q68FV2; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000005074; Expressed in thymus and 19 other tissues.
DR Genevisible; Q68FV2; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR InterPro; IPR029383; ARL6IP6.
DR PANTHER; PTHR28640; PTHR28640; 1.
DR Pfam; PF15062; ARL6IP6; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..223
FT /note="ADP-ribosylation factor-like protein 6-interacting
FT protein 6"
FT /id="PRO_0000307326"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 62
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N6S5"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 223 AA; 24596 MW; 26C55F3AC0A7F325 CRC64;
MSFVESWRSV GPRRRRQVTP GPVTRSVYSD YTQGNSWSED GDEGCDQVAR DLRAEFSARA
SSESKRAPLL PRIGDGSPVL PDKRNGIFPA TAAKRTQARR WPIQALSILC SLLFAVLLAF
LLAIAYLIVK ELHTENSKNE DVVDTGLLGF WSLLIISLTA GLSCCSFSWT VTYFDSFEPG
MFPPTPLSPA RFKKLTGHSF HMGYSMAILN GVVAALTVAW CLM
