ID   AR8BA_DANRE             Reviewed;         186 AA.
AC   Q6NZW8;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=ADP-ribosylation factor-like protein 8B-A;
GN   Name=arl8ba; Synonyms=arl8b; ORFNames=zgc:77187;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in lysosome motility. May play a role in
CC       chromosome segregation. {ECO:0000250|UniProtKB:Q9NVJ2}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q9NVJ2}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q9NVJ2}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q9NVJ2}. Note=Localizes with microtubules at the
CC       spindle mid-zone during mitosis. {ECO:0000250|UniProtKB:Q9NVJ2}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC065942; AAH65942.1; -; mRNA.
DR   RefSeq; NP_991129.1; NM_205566.1.
DR   AlphaFoldDB; Q6NZW8; -.
DR   SMR; Q6NZW8; -.
DR   STRING; 7955.ENSDARP00000019311; -.
DR   PaxDb; Q6NZW8; -.
DR   Ensembl; ENSDART00000014552; ENSDARP00000019311; ENSDARG00000006915.
DR   GeneID; 337424; -.
DR   KEGG; dre:337424; -.
DR   CTD; 337424; -.
DR   ZFIN; ZDB-GENE-030131-9370; arl8ba.
DR   eggNOG; KOG0075; Eukaryota.
DR   GeneTree; ENSGT00940000154861; -.
DR   HOGENOM; CLU_040729_10_0_1; -.
DR   InParanoid; Q6NZW8; -.
DR   OMA; SASWLWQ; -.
DR   OrthoDB; 1123043at2759; -.
DR   PhylomeDB; Q6NZW8; -.
DR   TreeFam; TF105470; -.
DR   PRO; PR:Q6NZW8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000006915; Expressed in spleen and 27 other tissues.
DR   ExpressionAtlas; Q6NZW8; baseline.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008089; P:anterograde axonal transport; IBA:GO_Central.
DR   GO; GO:0061909; P:autophagosome-lysosome fusion; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:1902774; P:late endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0032418; P:lysosome localization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   CDD; cd04159; Arl10_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR044154; Arl8a/8b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm; Cytoskeleton;
KW   Endosome; GTP-binding; Lysosome; Membrane; Mitosis; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..186
FT                   /note="ADP-ribosylation factor-like protein 8B-A"
FT                   /id="PRO_0000232926"
FT   INTRAMEM        1..19
FT                   /note="Note=Mediates targeting to membranes"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVJ2"
FT   BINDING         29..35
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVJ2"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62330"
FT   BINDING         130..133
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVJ2"
SQ   SEQUENCE   186 AA;  21494 MW;  64127071D299D167 CRC64;
     MLALINRLLD WFKSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI PTVGFNMRKV
     TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMVDAAD REKVEASRNE LHNLLDKPQL
     QGIPVLVLGN KRDLPNALDE KQLIEKMNLA AIQDREICCY SISCKEKDNI DITLQWLIQH
     SKSRRS