ID   ARA1_MAGO7              Reviewed;         707 AA.
AC   G4MNH3;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=L-arabinose-responsive transcription regulator ARA1;
GN   Name=ARA1; ORFNames=MGG_06954;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26790567; DOI=10.1002/1873-3468.12070;
RA   Klaubauf S., Zhou M., Lebrun M.H., de Vries R.P., Battaglia E.;
RT   "A novel L-arabinose-responsive regulator discovered in the rice-blast
RT   fungus Pyricularia oryzae (Magnaporthe oryzae).";
RL   FEBS Lett. 590:550-558(2016).
CC   -!- FUNCTION: Transcriptional activator of the arabinanolytic system.
CC       Involved in the regulation of extracellular arabinanolytic genes and in
CC       the regulation of the intracellular activities of L-arabinose catabolic
CC       genes in the pentose catabolic pathway (PCP) in response to the
CC       presence of L-arabinose. {ECO:0000269|PubMed:26790567}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- DISRUPTION PHENOTYPE: Shows no growth on L-arabinose and strong grwoth
CC       reduction on arabinan and arabinogalactan.
CC       {ECO:0000269|PubMed:26790567}.
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DR   EMBL; CM001231; EHA57087.1; -; Genomic_DNA.
DR   RefSeq; XP_003709699.1; XM_003709651.1.
DR   AlphaFoldDB; G4MNH3; -.
DR   SMR; G4MNH3; -.
DR   EnsemblFungi; MGG_06954T0; MGG_06954T0; MGG_06954.
DR   GeneID; 2685127; -.
DR   KEGG; mgr:MGG_06954; -.
DR   VEuPathDB; FungiDB:MGG_06954; -.
DR   eggNOG; ENOG502S9U8; Eukaryota.
DR   HOGENOM; CLU_014924_2_0_1; -.
DR   InParanoid; G4MNH3; -.
DR   OMA; MIAPCPV; -.
DR   OrthoDB; 352710at2759; -.
DR   PHI-base; PHI:5635; -.
DR   Proteomes; UP000009058; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR021858; Fun_TF.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF11951; Fungal_trans_2; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..707
FT                   /note="L-arabinose-responsive transcription regulator ARA1"
FT                   /id="PRO_0000438824"
FT   DNA_BIND        21..48
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          527..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           14..21
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
SQ   SEQUENCE   707 AA;  77153 MW;  38AA242FC5D3F8D5 CRC64;
     MLLFTKLAAP KAPKRRSRAG CTSCKERKKK CNEERPQCSR CAERGSSCVY EPVRPRQRRK
     RDSFITSLAD ASTNGSHQHE AEEDDHGARF DRFDACEDHL SQHQRVSHDW GHQPWQASMP
     DSFDDDLIFS PLDDTFDPNV LLAAAPLETS SVIINPDEDF TGPLSSTTQP RVLRYEEDDD
     DGEEEIDIGG GGAGLIGIKH DRRSSFTSTT TVATNTTAGN TIFSTDLTIC SPATVRSPLL
     EFTCPSFSEF SENPRQRSLV DHFCNVLSHL IVFREETGNP FQQLVLPLMR GGGGGGNNSP
     VADAVFALAG AHLEHRGVDV KGGEKSLYFH HRAIQGLAGL IRMHNAGVNR NEVLAAIMLL
     IYYEVLVQRG RSNIVEGHLK GALTVMCSNP EPLDSTGIFL ERAFRFYDVI AALSFGTAPL
     STAPAAGCLV PFPISAPTAT STLNNVDSLL GMATTLWPII HRLSALLPLK TDVANARDAG
     HNGKVAVLRT EFETTVGAVE AALLGWTPNL PTGWVLHESD PTKLVEDTTA AKDENSTGEE
     KRSGGDSARL HSILNNALAY RNSALVYLYR TVLSHPRDHP LVQRHANLSL RHCAATVEHQ
     GPMGALLWPL FVAACEAVTG ADRDTARTAF AAIDKRQGMT NIERAWDIVQ EVWRRAEGGT
     EETVRGEGVR SDTSPAQLSM ACSRELKGTA DMWRVVSKEM GVNIVFG