KDSB_SHEB8
ID KDSB_SHEB8 Reviewed; 245 AA.
AC A6WNW2;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase {ECO:0000255|HAMAP-Rule:MF_00057};
DE EC=2.7.7.90 {ECO:0000255|HAMAP-Rule:MF_00057};
DE AltName: Full=CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase {ECO:0000255|HAMAP-Rule:MF_00057};
GN Name=kdsB {ECO:0000255|HAMAP-Rule:MF_00057};
GN OrderedLocusNames=Shew185_2363;
OS Shewanella baltica (strain OS185).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=402882;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OS185;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Brettar I., Rodrigues J., Konstantinidis K., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome of Shewanella baltica OS185.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Activates KDO8N (a required 8-carbon sugar) for incorporation
CC into bacterial lipopolysaccharide in the Shewanella genus.
CC {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-
CC amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate;
CC Xref=Rhea:RHEA:49284, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:87091, ChEBI:CHEBI:91089; EC=2.7.7.90;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00057};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- SIMILARITY: Belongs to the KdsB family. {ECO:0000255|HAMAP-
CC Rule:MF_00057}.
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DR EMBL; CP000753; ABS08501.1; -; Genomic_DNA.
DR RefSeq; WP_012089331.1; NC_009665.1.
DR AlphaFoldDB; A6WNW2; -.
DR SMR; A6WNW2; -.
DR KEGG; sbm:Shew185_2363; -.
DR HOGENOM; CLU_065038_0_1_6; -.
DR OMA; MSIKEHE; -.
DR UniPathway; UPA00030; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008690; F:3-deoxy-manno-octulosonate cytidylyltransferase activity; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02517; CMP-KDO-Synthetase; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR HAMAP; MF_00057; KdsB; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR004528; KdsB.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR00466; kdsB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Lipopolysaccharide biosynthesis; Nucleotidyltransferase;
KW Transferase.
FT CHAIN 1..245
FT /note="8-amino-3,8-dideoxy-manno-octulosonate
FT cytidylyltransferase"
FT /id="PRO_0000370146"
SQ SEQUENCE 245 AA; 27477 MW; FD012BC4809A7973 CRC64;
MNVTLLIPAR YGSSRFPGKP LAPINGKPMI QHVYERASLA KGLTNIYVAT DDDRIKAAVE
GFGGKVVMTS PEAASGTDRI NDAINQLGLK DDDLVINLQG DQPLIDPTSI EQVISLFERH
PGEFEMATLG FEIVNKTELD DPMHVKMVFD NNNYALYFSR SRIPFGRDTQ DYPVYKHLGV
YAYTRKFVQA FAALPLGRLE DLEKLEQLRA LEYGHKIKIA ISAFDSIEVD TPEDIRKCEQ
RLAVD