KDSB_SHEON
ID KDSB_SHEON Reviewed; 245 AA.
AC Q8EEA9;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase {ECO:0000255|HAMAP-Rule:MF_00057};
DE EC=2.7.7.90 {ECO:0000255|HAMAP-Rule:MF_00057, ECO:0000269|PubMed:23413030};
DE AltName: Full=CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase {ECO:0000255|HAMAP-Rule:MF_00057};
GN Name=kdsB {ECO:0000255|HAMAP-Rule:MF_00057, ECO:0000303|PubMed:23413030};
GN OrderedLocusNames=SO_2478;
OS Shewanella oneidensis (strain MR-1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=211586;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR-1;
RX PubMed=12368813; DOI=10.1038/nbt749;
RA Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A.,
RA Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J.,
RA Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J.,
RA Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V.,
RA Smith H.O., Venter J.C., Nealson K.H., Fraser C.M.;
RT "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT Shewanella oneidensis.";
RL Nat. Biotechnol. 20:1118-1123(2002).
RN [2]
RP FUNCTION IN CMP-KDO8N FORMATION, AND CATALYTIC ACTIVITY.
RC STRAIN=MR-1;
RX PubMed=23413030; DOI=10.1074/jbc.m113.453324;
RA Gattis S.G., Chung H.S., Trent M.S., Raetz C.R.;
RT "The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the
RT lipopolysaccharide of Shewanella oneidensis.";
RL J. Biol. Chem. 288:9216-9225(2013).
CC -!- FUNCTION: Activates KDO8N (a required 8-carbon sugar) for incorporation
CC into bacterial lipopolysaccharide in the Shewanella genus.
CC {ECO:0000255|HAMAP-Rule:MF_00057, ECO:0000269|PubMed:23413030}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-
CC amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate;
CC Xref=Rhea:RHEA:49284, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:87091, ChEBI:CHEBI:91089; EC=2.7.7.90;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00057,
CC ECO:0000269|PubMed:23413030};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- SIMILARITY: Belongs to the KdsB family. {ECO:0000255|HAMAP-
CC Rule:MF_00057}.
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DR EMBL; AE014299; AAN55509.1; -; Genomic_DNA.
DR RefSeq; NP_718065.1; NC_004347.2.
DR RefSeq; WP_011072444.1; NZ_CP053946.1.
DR AlphaFoldDB; Q8EEA9; -.
DR SMR; Q8EEA9; -.
DR STRING; 211586.SO_2478; -.
DR PaxDb; Q8EEA9; -.
DR KEGG; son:SO_2478; -.
DR PATRIC; fig|211586.12.peg.2387; -.
DR eggNOG; COG1212; Bacteria.
DR HOGENOM; CLU_065038_0_1_6; -.
DR OMA; MSIKEHE; -.
DR OrthoDB; 1345588at2; -.
DR PhylomeDB; Q8EEA9; -.
DR BioCyc; MetaCyc:MON-19350; -.
DR BioCyc; SONE211586:G1GMP-2264-MON; -.
DR BRENDA; 2.7.7.90; 5706.
DR UniPathway; UPA00030; -.
DR Proteomes; UP000008186; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008690; F:3-deoxy-manno-octulosonate cytidylyltransferase activity; IBA:GO_Central.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02517; CMP-KDO-Synthetase; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR HAMAP; MF_00057; KdsB; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR004528; KdsB.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR00466; kdsB; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Lipopolysaccharide biosynthesis; Nucleotidyltransferase;
KW Reference proteome; Transferase.
FT CHAIN 1..245
FT /note="8-amino-3,8-dideoxy-manno-octulosonate
FT cytidylyltransferase"
FT /id="PRO_0000370152"
SQ SEQUENCE 245 AA; 27527 MW; E060B90B5E8D0D21 CRC64;
MNVTLLIPAR YGSSRFPGKP LAPINGKPMI QHVYERASLA KGLTNIYVAT DDERIKSAVE
GFGGKVVMTS PDAASGTDRI NDAINQLGLK DDDLVINLQG DQPLIDPTSI EQVISLFERH
PGEFEMATLG YEIVNKAELD DPMHVKMVFD NDYYALYFSR ARIPFGRDTK DYPVYKHLGV
YAYTRRFVQA FAALPLGRLE DLEKLEQLRA LEYGHKIKVA ISAFDSIEVD TPEDIRKCEQ
RLAVD