KDSB_SHEPC
ID KDSB_SHEPC Reviewed; 245 AA.
AC A4Y7B5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase {ECO:0000255|HAMAP-Rule:MF_00057};
DE EC=2.7.7.90 {ECO:0000255|HAMAP-Rule:MF_00057};
DE AltName: Full=CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase {ECO:0000255|HAMAP-Rule:MF_00057};
GN Name=kdsB {ECO:0000255|HAMAP-Rule:MF_00057};
GN OrderedLocusNames=Sputcn32_2127;
OS Shewanella putrefaciens (strain CN-32 / ATCC BAA-453).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=319224;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CN-32 / ATCC BAA-453;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Fredrickson J.,
RA Tiedje J., Richardson P.;
RT "Complete sequence of Shewanella putrefaciens CN-32.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Activates KDO8N (a required 8-carbon sugar) for incorporation
CC into bacterial lipopolysaccharide in the Shewanella genus.
CC {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-
CC amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate;
CC Xref=Rhea:RHEA:49284, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:87091, ChEBI:CHEBI:91089; EC=2.7.7.90;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00057};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00057}.
CC -!- SIMILARITY: Belongs to the KdsB family. {ECO:0000255|HAMAP-
CC Rule:MF_00057}.
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DR EMBL; CP000681; ABP75848.1; -; Genomic_DNA.
DR RefSeq; WP_011919382.1; NC_009438.1.
DR AlphaFoldDB; A4Y7B5; -.
DR SMR; A4Y7B5; -.
DR STRING; 319224.Sputcn32_2127; -.
DR GeneID; 45042587; -.
DR KEGG; spc:Sputcn32_2127; -.
DR eggNOG; COG1212; Bacteria.
DR HOGENOM; CLU_065038_0_1_6; -.
DR OMA; MSIKEHE; -.
DR UniPathway; UPA00030; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008690; F:3-deoxy-manno-octulosonate cytidylyltransferase activity; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02517; CMP-KDO-Synthetase; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR HAMAP; MF_00057; KdsB; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR004528; KdsB.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR00466; kdsB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Lipopolysaccharide biosynthesis; Nucleotidyltransferase;
KW Transferase.
FT CHAIN 1..245
FT /note="8-amino-3,8-dideoxy-manno-octulosonate
FT cytidylyltransferase"
FT /id="PRO_0000370155"
SQ SEQUENCE 245 AA; 27398 MW; 3DFDD76DF9714083 CRC64;
MNVILLIPAR YGSSRFPGKP LAPINGKPMI QHVYERASLA KGLTNIYVAT DDERIKATVE
GFGGKVVMTS PDAASGTDRI NEAIKLLGLK DDDLVINVQG DQPLIDPTAI EQLINLFERQ
PGEFEMATLG YEIVNKADID DPMQVKMVFD NNYYALYFSR SRIPFGRDTQ DYPVFKHLGI
YAYTSKFVQT FAALPLGRLE DLEKLEQLRA LEHGHKIKIA ISASNSLEVD RPEDIHKCEQ
RLAAS