ID   ARAA_BACTN              Reviewed;         509 AA.
AC   Q8AAW1;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=L-arabinose isomerase {ECO:0000255|HAMAP-Rule:MF_00519};
DE            EC=5.3.1.4 {ECO:0000255|HAMAP-Rule:MF_00519};
GN   Name=araA {ECO:0000255|HAMAP-Rule:MF_00519}; OrderedLocusNames=BT_0351;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: Catalyzes the conversion of L-arabinose to L-ribulose.
CC       {ECO:0000255|HAMAP-Rule:MF_00519}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-L-arabinopyranose = L-ribulose; Xref=Rhea:RHEA:14821,
CC         ChEBI:CHEBI:16880, ChEBI:CHEBI:40886; EC=5.3.1.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00519};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00519};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00519};
CC   -!- PATHWAY: Carbohydrate degradation; L-arabinose degradation via L-
CC       ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route):
CC       step 1/3. {ECO:0000255|HAMAP-Rule:MF_00519}.
CC   -!- SIMILARITY: Belongs to the arabinose isomerase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00519}.
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DR   EMBL; AE015928; AAO75458.1; -; Genomic_DNA.
DR   RefSeq; NP_809264.1; NC_004663.1.
DR   RefSeq; WP_008760642.1; NZ_UYXG01000016.1.
DR   AlphaFoldDB; Q8AAW1; -.
DR   SMR; Q8AAW1; -.
DR   STRING; 226186.BT_0351; -.
DR   PaxDb; Q8AAW1; -.
DR   PRIDE; Q8AAW1; -.
DR   EnsemblBacteria; AAO75458; AAO75458; BT_0351.
DR   GeneID; 60926311; -.
DR   KEGG; bth:BT_0351; -.
DR   PATRIC; fig|226186.12.peg.350; -.
DR   eggNOG; COG2160; Bacteria.
DR   HOGENOM; CLU_045663_0_0_10; -.
DR   InParanoid; Q8AAW1; -.
DR   OMA; HMLEICP; -.
DR   BRENDA; 5.3.1.4; 709.
DR   UniPathway; UPA00145; UER00565.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0008733; F:L-arabinose isomerase activity; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019569; P:L-arabinose catabolic process to xylulose 5-phosphate; IBA:GO_Central.
DR   Gene3D; 3.40.50.10940; -; 1.
DR   HAMAP; MF_00519; Arabinose_Isome; 1.
DR   InterPro; IPR024664; Ara_Isoase_C.
DR   InterPro; IPR038583; AraA_N_sf.
DR   InterPro; IPR004216; Fuc/Ara_isomerase_C.
DR   InterPro; IPR009015; Fucose_isomerase_N/cen_sf.
DR   InterPro; IPR003762; Lara_isomerase.
DR   PANTHER; PTHR38464; PTHR38464; 1.
DR   Pfam; PF11762; Arabinose_Iso_C; 1.
DR   Pfam; PF02610; Arabinose_Isome; 1.
DR   PIRSF; PIRSF001478; L-ara_isomerase; 1.
DR   SUPFAM; SSF50443; SSF50443; 1.
DR   SUPFAM; SSF53743; SSF53743; 1.
PE   3: Inferred from homology;
KW   Arabinose catabolism; Carbohydrate metabolism; Isomerase; Manganese;
KW   Metal-binding; Reference proteome.
FT   CHAIN           1..509
FT                   /note="L-arabinose isomerase"
FT                   /id="PRO_0000312601"
FT   BINDING         313
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00519"
FT   BINDING         340
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00519"
FT   BINDING         357
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00519"
FT   BINDING         456
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00519"
SQ   SEQUENCE   509 AA;  57174 MW;  DE04E4669834332C CRC64;
     MNNVFDQYEV WFVTGAQLLY GGDAVIAVDA HSNEMVNGLN ESGKLPVKVV YKGTANSSKE
     VEAVFKAANN DDKCVGVITW MHTFSPAKMW IHGLQQLKKP LLHLHTQFNK EIPWDTMDMD
     FMNLNQSAHG DREFGHICTR MRIRRKVVVG YWKEEETLHK IAVWMRVCAG WADSQDMLII
     RFGDQMNNVA VTDGDKVEAE QRMGYHVDYC PASELMEYHK DIKNADVDAL VATYFNDYDH
     DASLEDKSTE AYQKVWNAAK AELALRAILK AKGAKGFTTN FDDLGQTDGS YFDQIPGLAS
     QRLMAEGYGF GAEGDWKSAA LYRTVWVMNQ GLPKGCSFLE DYTLNFDGAN SSILQSHMLE
     ICPLIAANKP RLEVHFLGIG IRKSQTARLV FTSKTGTGCT ATVVDMGNRF RLIVNDVECI
     EPKPLPKLPV ASALWIPMPN LEVGAGAWIL AGGTHHSCFS YDLTAEYWED YAEIAGIEMV
     HINKDTTISC FKKELRMNEV YYMLNKALC