KEA6_ARATH
ID KEA6_ARATH Reviewed; 597 AA.
AC B5X0N6; Q9LYF1;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=K(+) efflux antiporter 6 {ECO:0000303|PubMed:11500563};
DE Short=AtKEA6 {ECO:0000303|PubMed:11500563};
DE Flags: Precursor;
GN Name=KEA6 {ECO:0000303|PubMed:11500563};
GN OrderedLocusNames=At5g11800 {ECO:0000312|Araport:AT5G11800};
GN ORFNames=T22P22.190 {ECO:0000312|EMBL:CAB87698.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [5]
RP FUNCTION, GENE FAMILY, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=24278440; DOI=10.1371/journal.pone.0081463;
RA Zheng S., Pan T., Fan L., Qiu Q.S.;
RT "A novel AtKEA gene family, homolog of bacterial K+/H+ antiporters, plays
RT potential roles in K+ homeostasis and osmotic adjustment in Arabidopsis.";
RL PLoS ONE 8:E81463-E81463(2013).
CC -!- FUNCTION: K(+)/H(+) antiporter involved in K(+) homeostasis and osmotic
CC adjustment. {ECO:0000269|PubMed:24278440}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in shoots and roots.
CC {ECO:0000269|PubMed:24278440}.
CC -!- INDUCTION: Down-regulated by high K(+). {ECO:0000269|PubMed:24278440}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. KEA (TC 2.A.37.1) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB87698.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL163814; CAB87698.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91722.1; -; Genomic_DNA.
DR EMBL; BT044605; ACI31305.1; -; mRNA.
DR PIR; T48539; T48539.
DR RefSeq; NP_196741.2; NM_121218.5.
DR AlphaFoldDB; B5X0N6; -.
DR SMR; B5X0N6; -.
DR BioGRID; 16331; 9.
DR IntAct; B5X0N6; 9.
DR STRING; 3702.AT5G11800.1; -.
DR PaxDb; B5X0N6; -.
DR PRIDE; B5X0N6; -.
DR ProteomicsDB; 250686; -.
DR EnsemblPlants; AT5G11800.1; AT5G11800.1; AT5G11800.
DR GeneID; 831053; -.
DR Gramene; AT5G11800.1; AT5G11800.1; AT5G11800.
DR KEGG; ath:AT5G11800; -.
DR Araport; AT5G11800; -.
DR TAIR; locus:2181910; AT5G11800.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_11_1_1; -.
DR InParanoid; B5X0N6; -.
DR OMA; EAKWIVS; -.
DR OrthoDB; 522572at2759; -.
DR PhylomeDB; B5X0N6; -.
DR PRO; PR:B5X0N6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; B5X0N6; baseline and differential.
DR Genevisible; B5X0N6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR045158; KEA4/5/6-like.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR16254; PTHR16254; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..597
FT /note="K(+) efflux antiporter 6"
FT /evidence="ECO:0000255"
FT /id="PRO_0000395102"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 597 AA; 64392 MW; 73C93956CAB4946E CRC64;
MVEGRRRRRF SLSSQQLALL LLLLSFFLCF SVASPRAISD SDLLDETVAN SSSSVASLNA
SSSSSLVKPK EGSFADIIDR ALEKEFNESD QNEVADPGSF NNSVAGQQAV LETVARVKST
KKNETKEEKR FQLHDVFNLN NDNRAEDTPT LIDRKDNVFI ISNSKSKYPV LQLDLRLISD
LVVVIVSATC GGIAFACAGQ PVITGYLLAG SIIGPGGLNF ISEMVQVETV AQFGVVFLLF
ALGLEFSTAK LKVVRSVAVL GGLLQILLFM FLCGITVSLC GGKRSEGVFV GAFLSMSSTA
VVLKFLMEKN STNSLHGQVT IGILILQDCA VGLLFALLPV LEGNSGIVHG MLSIGKVVVL
LLSFLAVLSI LSRTCIPWLL KLMVSLSSQT NELYQLAAVA FCLLVAWCSD KLGLSLELGS
FAAGVMISTT DLAEHTLEQI EPIRNLFAAL FLASIGMLVN VHFLWTHVDI LLASVILVII
IKTTIVTTVV KGFGYNNKTA LLVGISLAQI GEFAFVLLSR ASNLHLIEGK LYLLLLGTTA
LSLVTTPLVF KMIPAVVHLG ILLKWFSPDS TIEKGEIVRS ESGKQRMILM SRQSHSS
