KEFB_YERPY
ID KEFB_YERPY Reviewed; 602 AA.
AC B1JIU4;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Glutathione-regulated potassium-efflux system protein KefB {ECO:0000255|HAMAP-Rule:MF_01412};
DE AltName: Full=K(+)/H(+) antiporter {ECO:0000255|HAMAP-Rule:MF_01412};
GN Name=kefB {ECO:0000255|HAMAP-Rule:MF_01412}; OrderedLocusNames=YPK_0266;
OS Yersinia pseudotuberculosis serotype O:3 (strain YPIII).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=502800;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YPIII;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT "Complete sequence of Yersinia pseudotuberculosis YPIII.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Pore-forming subunit of a potassium efflux system that
CC confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
CC {ECO:0000255|HAMAP-Rule:MF_01412}.
CC -!- SUBUNIT: Interacts with the regulatory subunit KefG.
CC {ECO:0000255|HAMAP-Rule:MF_01412}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01412}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01412}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. KefB subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_01412}.
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DR EMBL; CP000950; ACA66579.1; -; Genomic_DNA.
DR RefSeq; WP_002212314.1; NZ_CP009792.1.
DR AlphaFoldDB; B1JIU4; -.
DR SMR; B1JIU4; -.
DR EnsemblBacteria; ACA66579; ACA66579; YPK_0266.
DR GeneID; 66843862; -.
DR KEGG; ypy:YPK_0266; -.
DR PATRIC; fig|502800.11.peg.872; -.
DR OMA; IRPFHDV; -.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0015503; F:glutathione-regulated potassium exporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR HAMAP; MF_01412; K_H_efflux_KefB; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004771; K/H_exchanger.
DR InterPro; IPR020884; K_H_efflux_KefB.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR00932; 2a37; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Potassium; Potassium transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..602
FT /note="Glutathione-regulated potassium-efflux system
FT protein KefB"
FT /id="PRO_1000145534"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
FT DOMAIN 402..524
FT /note="RCK N-terminal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01412"
SQ SEQUENCE 602 AA; 66328 MW; 3166D7C15AE7C80A CRC64;
MEGTGLLTAV LVFLFAAVVA VPIAQRLGIG AVLGYLIAGI AIGPWGLGFI RDVDEILHFS
ELGVVFLMFI IGLELNPAKL WQLRRSIFGV GAGQVVITAA VLGALLYFTQ FAWQAAVIGG
VGLAMSSTAM ALQLMREKGM NRNEGGQLGF SVLLFQDMAV IPALALIPIL AGNEGGANDW
VKIGLKIAAF AGMLIGGRYL LRPLFRYIVA SGVREVFTAA ALLVVLGSAL FMDALGLSMA
LGTFIAGILL AESEFQHELE IAIEPFKGLL LGLFFISVGM ALDLGVLFTH LLDVLLGVLA
LVFIKSAILY GLARVFGLRR SVRLQFAGVL SQGGEFAFVL FSAAFSQRVL NAEQLALLLV
VVTLSMMTTP LLMQVIDRIL VRRYNAQEES DEKPFVEDND PQVIIVGFGR FGQVIGRLLM
ANKMRITVLE RDVSAVSMMR KYGYKVYYGD ATELELLRAA GAEKAKAIVI TCNEPEDTMA
LVHLCQQHFP NLHILARARG RVEAHELLQN GVKDFTRETF SSALELGRKT LLELGMHPHQ
AYRAQQHFRR LDMRMLRELM PQHHGDVAQI SRIKEARREL EDIFQREMLH ESRQLDGWDE
YE
